Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy
The development of pollinosis in children and adolescents is determined by the influence of genetic and environmental factors. The pathogenetic basis of pollinosis in children and adolescents is the differentiation of Th0 to Th2, activation of Th2cells and increasing of the production of IL-4, IL-5,...
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| Format: | Article |
| Language: | Russian |
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Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2023-03-01
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| Series: | Аллергология и Иммунология в Педиатрии |
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| Online Access: | https://adair.elpub.ru/jour/article/view/10 |
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| _version_ | 1849344812953632768 |
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| author | I. I. Balabolkin |
| author_facet | I. I. Balabolkin |
| author_sort | I. I. Balabolkin |
| collection | DOAJ |
| description | The development of pollinosis in children and adolescents is determined by the influence of genetic and environmental factors. The pathogenetic basis of pollinosis in children and adolescents is the differentiation of Th0 to Th2, activation of Th2cells and increasing of the production of IL-4, IL-5, IL-13, sIgE, activation of mast cells, basophils, eosinophils, with following development of IgE-mediated allergic reaction after exposure to pollen allergens and the manifestation of clinical symptoms of pollinosis (allergic rhinitis, allergic conjunctivitis, bronchial asthma). Children and adolescents with pollinosis often develop cross-allergic reactions to plant-based foods. Pathogenetic pharmacotherapy (antihistamines of the second generation, topical corticosteroids, antileukotrienes, decongestants) allows to achieve control over the symptoms of pollinosis. Subcutaneous and sublingual ASIT are high effective, they reduce the severity of symptoms of pollinosis, decrease the risk of developing bronchial asthma and severe clinical forms of pollinosis. The sublingual ASIT is more safe than subcutaneous ASIT. |
| format | Article |
| id | doaj-art-a9bc415dd2164e28b15ca5b3e013835a |
| institution | Kabale University |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj-art-a9bc415dd2164e28b15ca5b3e013835a2025-08-20T03:42:34ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582023-03-010361410.24411/2500-1175-2020-100079Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapyI. I. Balabolkin0National Medical Research Center for Children's HealthThe development of pollinosis in children and adolescents is determined by the influence of genetic and environmental factors. The pathogenetic basis of pollinosis in children and adolescents is the differentiation of Th0 to Th2, activation of Th2cells and increasing of the production of IL-4, IL-5, IL-13, sIgE, activation of mast cells, basophils, eosinophils, with following development of IgE-mediated allergic reaction after exposure to pollen allergens and the manifestation of clinical symptoms of pollinosis (allergic rhinitis, allergic conjunctivitis, bronchial asthma). Children and adolescents with pollinosis often develop cross-allergic reactions to plant-based foods. Pathogenetic pharmacotherapy (antihistamines of the second generation, topical corticosteroids, antileukotrienes, decongestants) allows to achieve control over the symptoms of pollinosis. Subcutaneous and sublingual ASIT are high effective, they reduce the severity of symptoms of pollinosis, decrease the risk of developing bronchial asthma and severe clinical forms of pollinosis. The sublingual ASIT is more safe than subcutaneous ASIT.https://adair.elpub.ru/jour/article/view/10pollinosisallergic rhinitisallergic conjunctivitisbronchial asthmath2il-4il-5il-13sigepathogenetic pharmacotherapyasit |
| spellingShingle | I. I. Balabolkin Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy Аллергология и Иммунология в Педиатрии pollinosis allergic rhinitis allergic conjunctivitis bronchial asthma th2 il-4 il-5 il-13 sige pathogenetic pharmacotherapy asit |
| title | Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy |
| title_full | Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy |
| title_fullStr | Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy |
| title_full_unstemmed | Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy |
| title_short | Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy |
| title_sort | pollinosis in children and adolescents modern aspects of pathogenesis and tendencies in therapy |
| topic | pollinosis allergic rhinitis allergic conjunctivitis bronchial asthma th2 il-4 il-5 il-13 sige pathogenetic pharmacotherapy asit |
| url | https://adair.elpub.ru/jour/article/view/10 |
| work_keys_str_mv | AT iibalabolkin pollinosisinchildrenandadolescentsmodernaspectsofpathogenesisandtendenciesintherapy |