Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review
Sepsis is a health issue that affects millions of people worldwide. It was assumed that erythrocytes were affected by sepsis. However, in recent years, a number of studies have shown that erythrocytes affect sepsis as well. When a pathogen invades the human body, it infects the blood and organs, cau...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=2;spage=125;epage=133;aulast=Chan |
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| _version_ | 1850196204949864448 |
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| author | Chih-Yu Chan Ching-Feng Cheng Hao-Ai Shui Hui-Chen Ku Wen-Lin Su |
| author_facet | Chih-Yu Chan Ching-Feng Cheng Hao-Ai Shui Hui-Chen Ku Wen-Lin Su |
| author_sort | Chih-Yu Chan |
| collection | DOAJ |
| description | Sepsis is a health issue that affects millions of people worldwide. It was assumed that erythrocytes were affected by sepsis. However, in recent years, a number of studies have shown that erythrocytes affect sepsis as well. When a pathogen invades the human body, it infects the blood and organs, causing infection and sepsis-related symptoms. Pathogens change the internal environment, increasing the levels of reactive oxygen species, influencing erythrocyte morphology, and causing erythrocyte death, i.e., eryptosis. Characteristics of eryptosis include cell shrinkage, membrane blebbing, and surface exposure of phosphatidylserine (PS). Eryptotic erythrocytes increase immune cell proliferation, and through PS, attract macrophages that remove the infected erythrocytes. Erythrocyte-degraded hemoglobin derivatives and heme deteriorate infection; however, they could also be metabolized to a series of derivatives. The result that erythrocytes play an anti-infection role during sepsis provides new perspectives for treatment. This review focuses on erythrocytes during pathogenic infection and sepsis. |
| format | Article |
| id | doaj-art-a9bb5c9038f546ee848dc7f5a8232ef1 |
| institution | OA Journals |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-a9bb5c9038f546ee848dc7f5a8232ef12025-08-20T02:13:31ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562022-01-0134212513310.4103/tcmj.tcmj_58_21Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A reviewChih-Yu ChanChing-Feng ChengHao-Ai ShuiHui-Chen KuWen-Lin SuSepsis is a health issue that affects millions of people worldwide. It was assumed that erythrocytes were affected by sepsis. However, in recent years, a number of studies have shown that erythrocytes affect sepsis as well. When a pathogen invades the human body, it infects the blood and organs, causing infection and sepsis-related symptoms. Pathogens change the internal environment, increasing the levels of reactive oxygen species, influencing erythrocyte morphology, and causing erythrocyte death, i.e., eryptosis. Characteristics of eryptosis include cell shrinkage, membrane blebbing, and surface exposure of phosphatidylserine (PS). Eryptotic erythrocytes increase immune cell proliferation, and through PS, attract macrophages that remove the infected erythrocytes. Erythrocyte-degraded hemoglobin derivatives and heme deteriorate infection; however, they could also be metabolized to a series of derivatives. The result that erythrocytes play an anti-infection role during sepsis provides new perspectives for treatment. This review focuses on erythrocytes during pathogenic infection and sepsis.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=2;spage=125;epage=133;aulast=Chaneryptosiserythrocytehemoglobinhemesepsis |
| spellingShingle | Chih-Yu Chan Ching-Feng Cheng Hao-Ai Shui Hui-Chen Ku Wen-Lin Su Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review Tzu Chi Medical Journal eryptosis erythrocyte hemoglobin heme sepsis |
| title | Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review |
| title_full | Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review |
| title_fullStr | Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review |
| title_full_unstemmed | Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review |
| title_short | Erythrocyte degradation, metabolism, secretion, and communication with immune cells in the blood during sepsis: A review |
| title_sort | erythrocyte degradation metabolism secretion and communication with immune cells in the blood during sepsis a review |
| topic | eryptosis erythrocyte hemoglobin heme sepsis |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=2;spage=125;epage=133;aulast=Chan |
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