Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/579670 |
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| author | Guillaume Seret Yannick Le Meur Yves Renaudineau Pierre Youinou |
| author_facet | Guillaume Seret Yannick Le Meur Yves Renaudineau Pierre Youinou |
| author_sort | Guillaume Seret |
| collection | DOAJ |
| description | Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs. In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation. The present paper will explain the mechanisms through which such autoAbs may initiate nephritis. |
| format | Article |
| id | doaj-art-a9ba57bf124542d49b9f5a2ae244e92f |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a9ba57bf124542d49b9f5a2ae244e92f2025-08-20T02:20:41ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/579670579670Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus NephritisGuillaume Seret0Yannick Le Meur1Yves Renaudineau2Pierre Youinou3EA2216 “Immunology & Pathology” and IFR146 “ScInBios,” European University of Brittany, 29200 Brest, FranceEA2216 “Immunology & Pathology” and IFR146 “ScInBios,” European University of Brittany, 29200 Brest, FranceEA2216 “Immunology & Pathology” and IFR146 “ScInBios,” European University of Brittany, 29200 Brest, FranceEA2216 “Immunology & Pathology” and IFR146 “ScInBios,” European University of Brittany, 29200 Brest, FranceNot only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs. In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation. The present paper will explain the mechanisms through which such autoAbs may initiate nephritis.http://dx.doi.org/10.1155/2012/579670 |
| spellingShingle | Guillaume Seret Yannick Le Meur Yves Renaudineau Pierre Youinou Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis Clinical and Developmental Immunology |
| title | Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis |
| title_full | Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis |
| title_fullStr | Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis |
| title_full_unstemmed | Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis |
| title_short | Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis |
| title_sort | mesangial cell specific antibodies are central to the pathogenesis of lupus nephritis |
| url | http://dx.doi.org/10.1155/2012/579670 |
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