Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro
This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV st...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1501685/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850094708420771840 |
|---|---|
| author | Zhanding Cui Zhanding Cui Jinlong Liu Jinlong Wang Jinlong Wang Jing Zhang Yimei Cao Kun Li Zhixun Zhao Hong Yuan Xingwen Bai Xueqing Ma Pinghua Li Yuanfang Fu Huifang Bao Dong Li Qiang Zhang Zaixin Liu Kai Li Tong Xu Zengjun Lu |
| author_facet | Zhanding Cui Zhanding Cui Jinlong Liu Jinlong Wang Jinlong Wang Jing Zhang Yimei Cao Kun Li Zhixun Zhao Hong Yuan Xingwen Bai Xueqing Ma Pinghua Li Yuanfang Fu Huifang Bao Dong Li Qiang Zhang Zaixin Liu Kai Li Tong Xu Zengjun Lu |
| author_sort | Zhanding Cui |
| collection | DOAJ |
| description | This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains in vitro, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies. |
| format | Article |
| id | doaj-art-a9aedf535c3b45f286a9a1c41e5bc1cb |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-a9aedf535c3b45f286a9a1c41e5bc1cb2025-08-20T02:41:36ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-03-011110.3389/fnut.2024.15016851501685Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitroZhanding Cui0Zhanding Cui1Jinlong Liu2Jinlong Wang3Jinlong Wang4Jing Zhang5Yimei Cao6Kun Li7Zhixun Zhao8Hong Yuan9Xingwen Bai10Xueqing Ma11Pinghua Li12Yuanfang Fu13Huifang Bao14Dong Li15Qiang Zhang16Zaixin Liu17Kai Li18Tong Xu19Zengjun Lu20Key Laboratory of Preventive Veterinary Medicine, Department of Veterinary Medicine, Animal Science College, Hebei North University, Zhangjiakou, Hebei, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaInstitute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaKey Laboratory of Preventive Veterinary Medicine, Department of Veterinary Medicine, Animal Science College, Hebei North University, Zhangjiakou, Hebei, ChinaKey Laboratory of Preventive Veterinary Medicine, Department of Veterinary Medicine, Animal Science College, Hebei North University, Zhangjiakou, Hebei, ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaThis study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains in vitro, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.https://www.frontiersin.org/articles/10.3389/fnut.2024.1501685/fullPorcine Reproductive and Respiratory Syndromeformononetinantiviral agentmizoribineswine viral infections |
| spellingShingle | Zhanding Cui Zhanding Cui Jinlong Liu Jinlong Wang Jinlong Wang Jing Zhang Yimei Cao Kun Li Zhixun Zhao Hong Yuan Xingwen Bai Xueqing Ma Pinghua Li Yuanfang Fu Huifang Bao Dong Li Qiang Zhang Zaixin Liu Kai Li Tong Xu Zengjun Lu Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro Frontiers in Nutrition Porcine Reproductive and Respiratory Syndrome formononetin antiviral agent mizoribine swine viral infections |
| title | Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro |
| title_full | Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro |
| title_fullStr | Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro |
| title_full_unstemmed | Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro |
| title_short | Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro |
| title_sort | formononetin and mizoribine inhibit porcine reproductive and respiratory syndrome virus replication in vitro |
| topic | Porcine Reproductive and Respiratory Syndrome formononetin antiviral agent mizoribine swine viral infections |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1501685/full |
| work_keys_str_mv | AT zhandingcui formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT zhandingcui formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT jinlongliu formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT jinlongwang formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT jinlongwang formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT jingzhang formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT yimeicao formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT kunli formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT zhixunzhao formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT hongyuan formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT xingwenbai formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT xueqingma formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT pinghuali formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT yuanfangfu formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT huifangbao formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT dongli formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT qiangzhang formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT zaixinliu formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT kaili formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT tongxu formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro AT zengjunlu formononetinandmizoribineinhibitporcinereproductiveandrespiratorysyndromevirusreplicationinvitro |