The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems
OBJECTIVE: Obstetric problems have detrimental effects on both pregnancy and newborn. We aimed to examine the relationship between pregnancy complications and newborn morbidities. STUDY DESIGN: The newborns admitted to the neonatal intensive care unit between September 2019 and August 2022 were i...
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| Format: | Article |
| Language: | English |
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Medical Network
2023-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1382 |
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| author | Selcan Sinaci Gulsum Kadioglu Simsek Bedri Sakcak Izzet Ozgurluk Fuat Emre Canpolat Dilek Sahin |
| author_facet | Selcan Sinaci Gulsum Kadioglu Simsek Bedri Sakcak Izzet Ozgurluk Fuat Emre Canpolat Dilek Sahin |
| author_sort | Selcan Sinaci |
| collection | DOAJ |
| description |
OBJECTIVE: Obstetric problems have detrimental effects on both pregnancy and newborn. We aimed to examine the relationship between pregnancy complications and newborn morbidities.
STUDY DESIGN: The newborns admitted to the neonatal intensive care unit between September 2019 and August 2022 were included in this retrospective cross-sectional study. Antenatal morbidities and neonatal complications including low APGAR-score (<5), bronchopulmonary dysplasia, early neonatal sepsis, and early neonatal death were evaluated. Pearson-χ2 cross-tabs were used to compare two variables. A p-value <0.05 was determined statistically significant.
RESULTS: Among the 686 infants analyzed, 94 (13.7%) had early neonatal death, 264 (38.5%) had bronchopulmonary dysplasia, 259 (37.8%) had early neonatal sepsis, and 424 (61.9%) had feeding intolerance. Early neonatal sepsis was observed significantly higher in newborns whose mothers had urinary tract infection in the last two weeks (p<0.001), preterm premature rupture of membranes (p=0.006), or clinical chorioamnionitis (p<0.001). Early neonatal death was found significantly higher in pregnancies with preeclampsia (p<0.001), preterm premature rupture of membranes (p<0.001), clinical chorioamnionitis (p<0.001), or small-for-gestational-age (p<0.001). Preeclampsia and magnesium neuroprophylaxis were found significantly higher in neonates with feeding intolerance (p<0.001). Backward: LR logistic regression analysis based on early neonatal sepsis risk revealed that birth week, preterm premature rupture of membranes, clinical chorioamnionitis, small-for-gestational-age, and urinary tract infection were significant parameters affecting the risk of early neonatal sepsis (p<0.05).
CONCLUSION: Preventing premature births and cautious management of pregnancy complications may be helpful in reducing adverse neonatal outcomes. Early detection of high-risk pregnancies and transfer to a tertiary center may be helpful to improve neonatal outcomes.
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| format | Article |
| id | doaj-art-a9ab488195d8444c961ed63f5b56fecd |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-a9ab488195d8444c961ed63f5b56fecd2025-02-11T21:16:45ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182023-03-0129110.21613/GORM.2022.1382The Impact of Prenatal Diagnosis and Treatment on Early Neonatal ProblemsSelcan Sinaci0Gulsum Kadioglu Simsek1Bedri Sakcak2Izzet Ozgurluk3Fuat Emre Canpolat4Dilek Sahin5Ankara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City Hospital OBJECTIVE: Obstetric problems have detrimental effects on both pregnancy and newborn. We aimed to examine the relationship between pregnancy complications and newborn morbidities. STUDY DESIGN: The newborns admitted to the neonatal intensive care unit between September 2019 and August 2022 were included in this retrospective cross-sectional study. Antenatal morbidities and neonatal complications including low APGAR-score (<5), bronchopulmonary dysplasia, early neonatal sepsis, and early neonatal death were evaluated. Pearson-χ2 cross-tabs were used to compare two variables. A p-value <0.05 was determined statistically significant. RESULTS: Among the 686 infants analyzed, 94 (13.7%) had early neonatal death, 264 (38.5%) had bronchopulmonary dysplasia, 259 (37.8%) had early neonatal sepsis, and 424 (61.9%) had feeding intolerance. Early neonatal sepsis was observed significantly higher in newborns whose mothers had urinary tract infection in the last two weeks (p<0.001), preterm premature rupture of membranes (p=0.006), or clinical chorioamnionitis (p<0.001). Early neonatal death was found significantly higher in pregnancies with preeclampsia (p<0.001), preterm premature rupture of membranes (p<0.001), clinical chorioamnionitis (p<0.001), or small-for-gestational-age (p<0.001). Preeclampsia and magnesium neuroprophylaxis were found significantly higher in neonates with feeding intolerance (p<0.001). Backward: LR logistic regression analysis based on early neonatal sepsis risk revealed that birth week, preterm premature rupture of membranes, clinical chorioamnionitis, small-for-gestational-age, and urinary tract infection were significant parameters affecting the risk of early neonatal sepsis (p<0.05). CONCLUSION: Preventing premature births and cautious management of pregnancy complications may be helpful in reducing adverse neonatal outcomes. Early detection of high-risk pregnancies and transfer to a tertiary center may be helpful to improve neonatal outcomes. https://gorm.com.tr/index.php/GORM/article/view/1382ChorioamnionitisEarly neonatal deathEarly neonatal sepsis High-Risk Pregnancy Perinatal morbidity Preterm premature membrane rupture |
| spellingShingle | Selcan Sinaci Gulsum Kadioglu Simsek Bedri Sakcak Izzet Ozgurluk Fuat Emre Canpolat Dilek Sahin The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems Gynecology Obstetrics & Reproductive Medicine Chorioamnionitis Early neonatal death Early neonatal sepsis High-Risk Pregnancy Perinatal morbidity Preterm premature membrane rupture |
| title | The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems |
| title_full | The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems |
| title_fullStr | The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems |
| title_full_unstemmed | The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems |
| title_short | The Impact of Prenatal Diagnosis and Treatment on Early Neonatal Problems |
| title_sort | impact of prenatal diagnosis and treatment on early neonatal problems |
| topic | Chorioamnionitis Early neonatal death Early neonatal sepsis High-Risk Pregnancy Perinatal morbidity Preterm premature membrane rupture |
| url | https://gorm.com.tr/index.php/GORM/article/view/1382 |
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