Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials
Abstract Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged as a research hotspot, unveiling complex bidirectional communication between bone and brain. Studies indicate that bone and brain can influence each other’s homeostasis via mult...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-03-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-025-00404-5 |
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| _version_ | 1849390375546912768 |
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| author | Jiaze Yu Luli Ji Yongxian Liu Xiaogang Wang Jing Wang Changsheng Liu |
| author_facet | Jiaze Yu Luli Ji Yongxian Liu Xiaogang Wang Jing Wang Changsheng Liu |
| author_sort | Jiaze Yu |
| collection | DOAJ |
| description | Abstract Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged as a research hotspot, unveiling complex bidirectional communication between bone and brain. Studies indicate that bone and brain can influence each other’s homeostasis via multiple pathways, yet there is a dearth of systematic reviews in this area. This review comprehensively examines interactions across three key areas: the influence of bone-derived factors on brain function, the effects of brain-related diseases or injuries (BRDI) on bone health, and the concept of skeletal interoception. Additionally, the review discusses innovative approaches in biomaterial design inspired by bone-brain interaction mechanisms, aiming to facilitate bone-brain interactions through materiobiological effects to aid in the treatment of neurodegenerative and bone-related diseases. Notably, the integration of artificial intelligence (AI) in biomaterial design is highlighted, showcasing AI’s role in expediting the formulation of effective and targeted treatment strategies. In conclusion, this review offers vital insights into the mechanisms of bone-brain interaction and suggests advanced approaches to harness these interactions in clinical practice. These insights offer promising avenues for preventing and treating complex diseases impacting the skeleton and brain, underscoring the potential of interdisciplinary approaches in enhancing human health. |
| format | Article |
| id | doaj-art-a9ab1fa5659b45f4adcfbe14c8b6748e |
| institution | Kabale University |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-a9ab1fa5659b45f4adcfbe14c8b6748e2025-08-20T03:41:41ZengNature Publishing GroupBone Research2095-62312025-03-0113112010.1038/s41413-025-00404-5Bone-brain interaction: mechanisms and potential intervention strategies of biomaterialsJiaze Yu0Luli Ji1Yongxian Liu2Xiaogang Wang3Jing Wang4Changsheng Liu5The State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyThe State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyThe State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyThe State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyThe State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyThe State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyAbstract Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged as a research hotspot, unveiling complex bidirectional communication between bone and brain. Studies indicate that bone and brain can influence each other’s homeostasis via multiple pathways, yet there is a dearth of systematic reviews in this area. This review comprehensively examines interactions across three key areas: the influence of bone-derived factors on brain function, the effects of brain-related diseases or injuries (BRDI) on bone health, and the concept of skeletal interoception. Additionally, the review discusses innovative approaches in biomaterial design inspired by bone-brain interaction mechanisms, aiming to facilitate bone-brain interactions through materiobiological effects to aid in the treatment of neurodegenerative and bone-related diseases. Notably, the integration of artificial intelligence (AI) in biomaterial design is highlighted, showcasing AI’s role in expediting the formulation of effective and targeted treatment strategies. In conclusion, this review offers vital insights into the mechanisms of bone-brain interaction and suggests advanced approaches to harness these interactions in clinical practice. These insights offer promising avenues for preventing and treating complex diseases impacting the skeleton and brain, underscoring the potential of interdisciplinary approaches in enhancing human health.https://doi.org/10.1038/s41413-025-00404-5 |
| spellingShingle | Jiaze Yu Luli Ji Yongxian Liu Xiaogang Wang Jing Wang Changsheng Liu Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials Bone Research |
| title | Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials |
| title_full | Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials |
| title_fullStr | Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials |
| title_full_unstemmed | Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials |
| title_short | Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials |
| title_sort | bone brain interaction mechanisms and potential intervention strategies of biomaterials |
| url | https://doi.org/10.1038/s41413-025-00404-5 |
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