Effect of allopurinol on albuminuria in type 2 diabetic kidney disease with hyperuricemia
Objective To evaluate the therapeutic effect of allopurinol on albuminuria in patients with? type 2 diabetic kidney disease combined with hyperuricemia. Methods Sixty-one patients with type 2diabetic kidney disease combined with hyperuricemia were randomly divided into two groups: research group( n...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2017-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57918214&Fpath=home&index=0 |
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| Summary: | Objective To evaluate the therapeutic effect of allopurinol on albuminuria in patients with? type 2 diabetic kidney disease combined with hyperuricemia. Methods Sixty-one patients with type 2diabetic kidney disease combined with hyperuricemia were randomly divided into two groups: research group( n = 31) and control group( n = 30). Patients in research group received routine treatment and low dose of allopurinol for 6 months,and those in control group were only treated with routine treatment. The fasting blood glucose( FBG),postprandial two-hour blood glucose( 2h PBG),hemoglobin A1c( HbA1c),serum uric acid( SUA),blood urea nitrogen( BUN),serum creatinine( SCr),triacylglycerol( TG),total cholesterol( TC),low density lipoprotein cholesterol( LDL-C),high density lipoprotein cholesterol( HDL-C),blood high-sensitivity creactive protein( hs-CRP),interleukin-6( IL-6),tumor necrosis factor-alpha( TNF-α),albumin-to-creatinine ratio( ACR),urine albumin excretion( MAU),fasting insulin( FINS) and insulin resistance index( HOMA-IR) were evaluated pre-and post-treatment. Results Before the treatment,there were no significant differences in the general information and biochemical data between the two groups( P > 0. 05). Six months later,the levels of SUA,hs-CRP,IL-6,TNF-α,MAU,ACR,FBG,FINS and HOMA-IR in the research group were significantly decreased as compared with those in the control group( P< 0. 001). Conclusions Allopurinol is an effective in the treatment of albuminuria in patients with type 2diabetes mellitus combined with hyperuricemia. It can protect renal function in early stage through controlling SUA and reducing insulin resistance to reduce urinary protein excretion. |
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| ISSN: | 1671-2390 |