Diabetes Control and Clinical Outcomes in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
<i>Background</i>: Type 2 diabetes mellitus (T2DM) is common among patients with chronic obstructive pulmonary disease (COPD). We examined the association between glycemic control and clinical outcomes in patients with COPD exacerbation and T2DM. <i>Methods</i>: A retrospecti...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Diabetology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4540/6/7/66 |
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| Summary: | <i>Background</i>: Type 2 diabetes mellitus (T2DM) is common among patients with chronic obstructive pulmonary disease (COPD). We examined the association between glycemic control and clinical outcomes in patients with COPD exacerbation and T2DM. <i>Methods</i>: A retrospective study of patients with T2DM and COPD exacerbation comparing controlled (HbA1c < 7.5%) to uncontrolled (HbA1c ≥ 7.5%) glycemia prior to admission. The primary endpoint is defined as a composite of 6-month rehospitalization/mortality. Secondary endpoints included 6-month mortality and 6-month readmission. <i>Results</i>: Of 426 admissions, 179 (42%) had uncontrolled glycemia. The risk of rehospitalization/mortality was significantly increased in the uncontrolled group in univariate (HR1.6, 95%CI 1.11–2.3, <i>p</i> = 0.01) and multivariate (HR 1.82, 95%CI 1.24–2.67, <i>p</i> = 0.002) analyses. The risk of 6-month rehospitalization was increased in the uncontrolled group in both univariate (HR1.94, 95%CI 1.16–3.23, <i>p</i> = 0.011) and multivariate (HR1.98, 95%CI 1.19–3.27, <i>p</i> = 0.008) analyses. No difference was found between 6-month mortality risks. <i>Conclusions</i>: Optimal glycemic control may improve COPD management and reduce adverse outcomes. |
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| ISSN: | 2673-4540 |