Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting
Abstract In the patients receiving coronary artery bypass grafting (CABG), arterial stiffness is an independent predictor of disease-related mortality. Higher serum levels of big endothelin-1 (BigET-1) are associated with arterial stiffness. The present study aimed to determine the association betwe...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-08181-1 |
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| author | Jin-You Jhan Jian-Hong Lin Kun-Ta Yang Bang-Gee Hsu Jui-Chih Chang |
| author_facet | Jin-You Jhan Jian-Hong Lin Kun-Ta Yang Bang-Gee Hsu Jui-Chih Chang |
| author_sort | Jin-You Jhan |
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| description | Abstract In the patients receiving coronary artery bypass grafting (CABG), arterial stiffness is an independent predictor of disease-related mortality. Higher serum levels of big endothelin-1 (BigET-1) are associated with arterial stiffness. The present study aimed to determine the association between serum BigET-1 levels and arterial stiffness in patients undergoing CABG. A total of 90 patients undergoing CABG were enrolled in the study. Serum levels of BigET-1 are examined with a commercial sandwich enzyme immunoassay. If carotid–femoral pulse wave velocity (cfPWV) > 10 m/s, arterial stiffness is diagnosed. In the study cohort, 30 (33.3%) patients with arterial stiffness were older and had lower body mass index, higher rates of diabetes mellitus and hypertension, higher systolic and diastolic blood pressures, and higher serum BigET-1 levels compared to the controls. Multivariable logistic regression analysis revealed that serum BigET-1 > 1 pg/mL was an independent predictor of arterial stiffness (odds ratio 17.492, 95% confidence interval 2.728–112.147, p = 0.003). Multivariable linear regression analysis revealed that cfPWV significantly correlated with age (β = 0.238, adjusted R2 change = 0.043, p = 0.004), systolic blood pressure (β = 0.251, adjusted R2 change = 0.102, p = 0.002), and BigET-1 level (β = 0.533, adjusted R2 change = 0.387, p < 0.001). Increased serum BigET-1 levels were associated with arterial stiffness in patients undergoing CABG. |
| format | Article |
| id | doaj-art-a9a7bfbc9aee4e7284ec27fe06e44870 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-a9a7bfbc9aee4e7284ec27fe06e448702025-08-20T03:03:40ZengNature PortfolioScientific Reports2045-23222025-07-011511610.1038/s41598-025-08181-1Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass graftingJin-You Jhan0Jian-Hong Lin1Kun-Ta Yang2Bang-Gee Hsu3Jui-Chih Chang4Division of Cardiovascular Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDivision of Experimental Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Physiology, School of Medicine, Tzu Chi UniversityDivision of Nephrology, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDivision of Cardiovascular Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationAbstract In the patients receiving coronary artery bypass grafting (CABG), arterial stiffness is an independent predictor of disease-related mortality. Higher serum levels of big endothelin-1 (BigET-1) are associated with arterial stiffness. The present study aimed to determine the association between serum BigET-1 levels and arterial stiffness in patients undergoing CABG. A total of 90 patients undergoing CABG were enrolled in the study. Serum levels of BigET-1 are examined with a commercial sandwich enzyme immunoassay. If carotid–femoral pulse wave velocity (cfPWV) > 10 m/s, arterial stiffness is diagnosed. In the study cohort, 30 (33.3%) patients with arterial stiffness were older and had lower body mass index, higher rates of diabetes mellitus and hypertension, higher systolic and diastolic blood pressures, and higher serum BigET-1 levels compared to the controls. Multivariable logistic regression analysis revealed that serum BigET-1 > 1 pg/mL was an independent predictor of arterial stiffness (odds ratio 17.492, 95% confidence interval 2.728–112.147, p = 0.003). Multivariable linear regression analysis revealed that cfPWV significantly correlated with age (β = 0.238, adjusted R2 change = 0.043, p = 0.004), systolic blood pressure (β = 0.251, adjusted R2 change = 0.102, p = 0.002), and BigET-1 level (β = 0.533, adjusted R2 change = 0.387, p < 0.001). Increased serum BigET-1 levels were associated with arterial stiffness in patients undergoing CABG.https://doi.org/10.1038/s41598-025-08181-1 |
| spellingShingle | Jin-You Jhan Jian-Hong Lin Kun-Ta Yang Bang-Gee Hsu Jui-Chih Chang Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting Scientific Reports |
| title | Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting |
| title_full | Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting |
| title_fullStr | Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting |
| title_full_unstemmed | Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting |
| title_short | Serum big endothelin-1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting |
| title_sort | serum big endothelin 1 is a significant biomarker of arterial stiffness in patients undergoing coronary artery bypass grafting |
| url | https://doi.org/10.1038/s41598-025-08181-1 |
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