Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica
In Salmonella enterica, aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme. When purH is eliminated in an otherwise wild-type strain, AICAR accumulates and indirectly inhibits synthesis of the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2017-11-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/untargeted-metabolomics-confirms-and-extends-the-understanding-of-the-impact-of-aminoimidazole-carboxamide-ribotide-aicar-in-the-metabolic-network-of-salmonella-enterica/ |
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