Spectrum of Hyperaldosteronism, Opportunities for Diagnosis
Primary aldosteronism (PA) is a common cause of secondary hypertension. It is characterized by renin-independent overproduction of aldosterone by the adrenal glands. Recent data indicate higher prevalence of PA than previously thought. The clinical presentation varies depending on the severity of al...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-11-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0383 |
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| author | Jan Zeman Karel Pacak Gonzalo J. Acosta Hans K. Ghayee Mohamad Anas Sukkari |
| author_facet | Jan Zeman Karel Pacak Gonzalo J. Acosta Hans K. Ghayee Mohamad Anas Sukkari |
| author_sort | Jan Zeman |
| collection | DOAJ |
| description | Primary aldosteronism (PA) is a common cause of secondary hypertension. It is characterized by renin-independent overproduction of aldosterone by the adrenal glands. Recent data indicate higher prevalence of PA than previously thought. The clinical presentation varies depending on the severity of aldosterone hypersecretion. Several studies suggest that PA manifests as a continuous spectrum. We present 2 clinical scenarios that highlight the challenges clinicians face while interpreting the biochemical work-up for PA. We emphasize the importance of understanding the pathophysiology of PA while interpreting borderline results. The aim is to underscore the importance of early recognition and treatment of PA, which can improve outcomes. |
| format | Article |
| id | doaj-art-a99e2caac75d493895d6afcc30ba2c7f |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-a99e2caac75d493895d6afcc30ba2c7f2025-08-20T03:18:48ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-11-0131110.7326/aimcc.2024.0383Spectrum of Hyperaldosteronism, Opportunities for DiagnosisJan Zeman0Karel Pacak1Gonzalo J. Acosta2Hans K. Ghayee3Mohamad Anas Sukkari41Department of Internal Medicine, University of Connecticut, Farmington, Connecticut2Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland3Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida4Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida and Malcom Randall VA Medical Center, Gainesville, Florida4Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida and Malcom Randall VA Medical Center, Gainesville, FloridaPrimary aldosteronism (PA) is a common cause of secondary hypertension. It is characterized by renin-independent overproduction of aldosterone by the adrenal glands. Recent data indicate higher prevalence of PA than previously thought. The clinical presentation varies depending on the severity of aldosterone hypersecretion. Several studies suggest that PA manifests as a continuous spectrum. We present 2 clinical scenarios that highlight the challenges clinicians face while interpreting the biochemical work-up for PA. We emphasize the importance of understanding the pathophysiology of PA while interpreting borderline results. The aim is to underscore the importance of early recognition and treatment of PA, which can improve outcomes.https://www.acpjournals.org/doi/10.7326/aimcc.2024.0383 |
| spellingShingle | Jan Zeman Karel Pacak Gonzalo J. Acosta Hans K. Ghayee Mohamad Anas Sukkari Spectrum of Hyperaldosteronism, Opportunities for Diagnosis Annals of Internal Medicine: Clinical Cases |
| title | Spectrum of Hyperaldosteronism, Opportunities for Diagnosis |
| title_full | Spectrum of Hyperaldosteronism, Opportunities for Diagnosis |
| title_fullStr | Spectrum of Hyperaldosteronism, Opportunities for Diagnosis |
| title_full_unstemmed | Spectrum of Hyperaldosteronism, Opportunities for Diagnosis |
| title_short | Spectrum of Hyperaldosteronism, Opportunities for Diagnosis |
| title_sort | spectrum of hyperaldosteronism opportunities for diagnosis |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0383 |
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