Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review
Mpox has re-emerged, particularly with the spread of Clade Ib in 2024 and recent outbreaks have raised concerns about its impact on pregnant women. Limited data suggest increased risks of adverse outcomes such as stillbirths and miscarriages, but understanding of mpox in pregnancy remains incomplete...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125001078 |
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| author | Benedetta Rossi Giorgio Tiecco Jacopo Logiudice Roberta Gerami Francesca Bertoni Lina Rachele Tomasoni Francesco Castelli Eugenia Quiros-Roldan |
| author_facet | Benedetta Rossi Giorgio Tiecco Jacopo Logiudice Roberta Gerami Francesca Bertoni Lina Rachele Tomasoni Francesco Castelli Eugenia Quiros-Roldan |
| author_sort | Benedetta Rossi |
| collection | DOAJ |
| description | Mpox has re-emerged, particularly with the spread of Clade Ib in 2024 and recent outbreaks have raised concerns about its impact on pregnant women. Limited data suggest increased risks of adverse outcomes such as stillbirths and miscarriages, but understanding of mpox in pregnancy remains incomplete. A narrative review of literature was conducted, focusing on maternal-fetal transmission and the implications of different MPXV clades. The spread of Clade Ib, first identified in 2023, has heightened concerns about vertical transmission, particularly in rural African regions where access to diagnostic tools and treatments is limited. The risk of vertical transmission has become a pressing concern, considering the high transmission rates of Clade Ib. Despite limited data, maternal-fetal transmission has been documented, with serious fetal outcomes such as stillbirths and hydrops fetalis. Continued research and surveillance are critical to developing effective clinical guidelines and public health interventions, especially for managing mpox in pregnancy. |
| format | Article |
| id | doaj-art-a99e251e05dc448eab1bd2efbc6586e2 |
| institution | DOAJ |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-a99e251e05dc448eab1bd2efbc6586e22025-08-20T03:08:24ZengElsevierJournal of Infection and Public Health1876-03412025-05-0118510275810.1016/j.jiph.2025.102758Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative reviewBenedetta Rossi0Giorgio Tiecco1Jacopo Logiudice2Roberta Gerami3Francesca Bertoni4Lina Rachele Tomasoni5Francesco Castelli6Eugenia Quiros-Roldan7Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, Italy; Department of Experimental Medicine and Public Health, School of Advanced Studies, University of Camerino, Camerino, ItalyDepartment of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, ItalyDepartment of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, ItalyDepartment of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, ItalyDepartment of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, ItalyUnit of Infectious and Tropical Diseases, ASST Spedali Civili di Brescia, Brescia 25123, ItalyDepartment of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, ItalyDepartment of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia 25123, Italy; Corresponding author.Mpox has re-emerged, particularly with the spread of Clade Ib in 2024 and recent outbreaks have raised concerns about its impact on pregnant women. Limited data suggest increased risks of adverse outcomes such as stillbirths and miscarriages, but understanding of mpox in pregnancy remains incomplete. A narrative review of literature was conducted, focusing on maternal-fetal transmission and the implications of different MPXV clades. The spread of Clade Ib, first identified in 2023, has heightened concerns about vertical transmission, particularly in rural African regions where access to diagnostic tools and treatments is limited. The risk of vertical transmission has become a pressing concern, considering the high transmission rates of Clade Ib. Despite limited data, maternal-fetal transmission has been documented, with serious fetal outcomes such as stillbirths and hydrops fetalis. Continued research and surveillance are critical to developing effective clinical guidelines and public health interventions, especially for managing mpox in pregnancy.http://www.sciencedirect.com/science/article/pii/S1876034125001078MonkeypoxMpoxMPXPregnancyVertical transmissionClade 1b |
| spellingShingle | Benedetta Rossi Giorgio Tiecco Jacopo Logiudice Roberta Gerami Francesca Bertoni Lina Rachele Tomasoni Francesco Castelli Eugenia Quiros-Roldan Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review Journal of Infection and Public Health Monkeypox Mpox MPX Pregnancy Vertical transmission Clade 1b |
| title | Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review |
| title_full | Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review |
| title_fullStr | Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review |
| title_full_unstemmed | Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review |
| title_short | Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review |
| title_sort | mpox in pregnancy unraveling the maternal fetal risks of a re emerging disease a narrative review |
| topic | Monkeypox Mpox MPX Pregnancy Vertical transmission Clade 1b |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125001078 |
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