THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia–reperfusion injury by inducing ferroptosis in endothelial cells

THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia–reperfusion injury by inducing ferroptosis in endothelial cells

Abstract Macrophages play a critical role in the development of acute ischemic stroke (AIS). Cerebral ischemia–reperfusion injury (CIRI) is a pivotal pathological process that exacerbates AIS, with exosomes act as crucial mediators. However, the effects and mechanisms of action of macrophage-derived...

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Bibliographic Details
Main Authors: Chang Liu, Haijing Sui, Zhixi Li, Zhenyu Sun, Chenglong Li, Guangmin Chen, Zhaoxue Ma, Hang Cao, Hongjie Xi
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Cerebral ischemia–reperfusion injury
Macrophage
Endothelial cells
Exosomes
Online Access:https://doi.org/10.1186/s12974-025-03382-x
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https://doi.org/10.1186/s12974-025-03382-x

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