Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions
Abstract Background Fatigue and inactivity are linked to decreased health-related quality of life (HRQoL) in chronic conditions. A multidimensional approach to activity pacing may improve HRQoL by promoting physical activity (PA) and alleviating fatigue. Addressing fatigue across chronic conditions...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Sports Science, Medicine and Rehabilitation |
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| Online Access: | https://doi.org/10.1186/s13102-025-01057-x |
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| author | Ioulia Barakou Bregje L. Seves Ulric S. Abonie Tracy Finch Kate L. Hackett Florentina J. Hettinga |
| author_facet | Ioulia Barakou Bregje L. Seves Ulric S. Abonie Tracy Finch Kate L. Hackett Florentina J. Hettinga |
| author_sort | Ioulia Barakou |
| collection | DOAJ |
| description | Abstract Background Fatigue and inactivity are linked to decreased health-related quality of life (HRQoL) in chronic conditions. A multidimensional approach to activity pacing may improve HRQoL by promoting physical activity (PA) and alleviating fatigue. Addressing fatigue across chronic conditions is crucial, especially when underlying causes are unknown. This study aimed to (1) examine associations between HRQoL, fatigue, pacing, risk of overactivity, PA, and self-regulation of PA in adults with chronic conditions and (2) examine if these associations differ across HRQoL domains: physical, social, emotional, and functional well-being. Methods Sixty-six adults with chronic conditions were recruited from UK fatigue clinics and the community. HRQoL, pacing, risk of overactivity, PA, and self-regulation of PA were assessed with standardised questionnaires and Actigraph monitor. Associations were analysed with linear mixed models, correcting for confounders. Results HRQoL was significantly associated with fatigue (B=-7.82), pacing (B=-0.23), and self-regulation of PA (B = 0.11). Interaction effects revealed fatigue’s impact on HRQoL varied significantly in physical (β=-13.49), social (β=-6.81), and emotional (β=-4.10) domains. Pacing showed significant differences in physical (β=-0.49), social (β=-7.12), and emotional (β=-7.45) domains. Perceived overactivity differed in social domain (β=-6.27), while device-based PA differed in physical (β = 0.35) and social (β = 5.73). Conclusion The negative association between fatigue and HRQoL underscores the importance of effective fatigue management. Higher pacing engagement and lower HRQoL may indicate higher fatigue. Positive associations between self-regulation and PA with HRQoL emphasise benefits of appropriate PA behaviours. The stronger impact of decreased fatigue, increased pacing, and PA on physical well-being suggests a multidimensional fatigue management approach. |
| format | Article |
| id | doaj-art-a99d7387c91a4bb3bf47f2ee064ab1f2 |
| institution | Kabale University |
| issn | 2052-1847 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Sports Science, Medicine and Rehabilitation |
| spelling | doaj-art-a99d7387c91a4bb3bf47f2ee064ab1f22025-02-02T12:36:19ZengBMCBMC Sports Science, Medicine and Rehabilitation2052-18472025-01-0117111510.1186/s13102-025-01057-xHealth-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditionsIoulia Barakou0Bregje L. Seves1Ulric S. Abonie2Tracy Finch3Kate L. Hackett4Florentina J. Hettinga5Department of Nursing, Midwifery & Health, Northumbria UniversityDepartment of Rehabilitation Medicine, University Medical Center Groningen, University of GroningenDepartment of Sport Exercise and Rehabilitation, Northumbria UniversityDepartment of Nursing, Midwifery & Health, Northumbria UniversityDepartment of Social Work, Education and Community Wellbeing, Northumbria UniversityDepartment of Sport Exercise and Rehabilitation, Northumbria UniversityAbstract Background Fatigue and inactivity are linked to decreased health-related quality of life (HRQoL) in chronic conditions. A multidimensional approach to activity pacing may improve HRQoL by promoting physical activity (PA) and alleviating fatigue. Addressing fatigue across chronic conditions is crucial, especially when underlying causes are unknown. This study aimed to (1) examine associations between HRQoL, fatigue, pacing, risk of overactivity, PA, and self-regulation of PA in adults with chronic conditions and (2) examine if these associations differ across HRQoL domains: physical, social, emotional, and functional well-being. Methods Sixty-six adults with chronic conditions were recruited from UK fatigue clinics and the community. HRQoL, pacing, risk of overactivity, PA, and self-regulation of PA were assessed with standardised questionnaires and Actigraph monitor. Associations were analysed with linear mixed models, correcting for confounders. Results HRQoL was significantly associated with fatigue (B=-7.82), pacing (B=-0.23), and self-regulation of PA (B = 0.11). Interaction effects revealed fatigue’s impact on HRQoL varied significantly in physical (β=-13.49), social (β=-6.81), and emotional (β=-4.10) domains. Pacing showed significant differences in physical (β=-0.49), social (β=-7.12), and emotional (β=-7.45) domains. Perceived overactivity differed in social domain (β=-6.27), while device-based PA differed in physical (β = 0.35) and social (β = 5.73). Conclusion The negative association between fatigue and HRQoL underscores the importance of effective fatigue management. Higher pacing engagement and lower HRQoL may indicate higher fatigue. Positive associations between self-regulation and PA with HRQoL emphasise benefits of appropriate PA behaviours. The stronger impact of decreased fatigue, increased pacing, and PA on physical well-being suggests a multidimensional fatigue management approach.https://doi.org/10.1186/s13102-025-01057-xExerciseChronic diseaseFatigueEnergy regulationLong-term conditions |
| spellingShingle | Ioulia Barakou Bregje L. Seves Ulric S. Abonie Tracy Finch Kate L. Hackett Florentina J. Hettinga Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions BMC Sports Science, Medicine and Rehabilitation Exercise Chronic disease Fatigue Energy regulation Long-term conditions |
| title | Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions |
| title_full | Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions |
| title_fullStr | Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions |
| title_full_unstemmed | Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions |
| title_short | Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions |
| title_sort | health related quality of life associated with fatigue physical activity and activity pacing in adults with chronic conditions |
| topic | Exercise Chronic disease Fatigue Energy regulation Long-term conditions |
| url | https://doi.org/10.1186/s13102-025-01057-x |
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