The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke
IntroductionWhole blood viscosity (WBV), reflecting the intrinsic resistance of blood flow, is an established predictor of stroke events in individuals. This study aims to correlate the WBV at different shear rates with the outcome of mechanical thrombectomy, known to be an effective treatment for l...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Stroke |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fstro.2025.1517343/full |
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| author | Monika Thapa Jordyn Courville Reese Leonhard Prabandh Buchhanolla Mohammad Abdurrehman Sheikh Rahul Shah Prashant Rai Himanshu Chokhawala Md Ismail Hossain Mohammad Alfrad Nobel Bhuiyan J. Dedrick Jordan Roger E. Kelley |
| author_facet | Monika Thapa Jordyn Courville Reese Leonhard Prabandh Buchhanolla Mohammad Abdurrehman Sheikh Rahul Shah Prashant Rai Himanshu Chokhawala Md Ismail Hossain Mohammad Alfrad Nobel Bhuiyan J. Dedrick Jordan Roger E. Kelley |
| author_sort | Monika Thapa |
| collection | DOAJ |
| description | IntroductionWhole blood viscosity (WBV), reflecting the intrinsic resistance of blood flow, is an established predictor of stroke events in individuals. This study aims to correlate the WBV at different shear rates with the outcome of mechanical thrombectomy, known to be an effective treatment for large vessel occlusion (LVO) stroke.MethodThis is a single-center retrospective study conducted at our comprehensive stroke center. The charts of 317 patients who underwent mechanical thrombectomy within 6 h of LVO stroke presentation were reviewed. The modified Rankin score (mRS) at discharge was used as the outcome measure, with individuals categorized as low (0–2) or high (3–6). WBV at different shear rates was calculated using De Simone's Formula. The T-test and Chi-square test were used to compare baseline continuous and categorical data, respectively, amongst the mRS study groups. We utilized multivariable logistic regression analyses to identify the independent risk factors associated with the outcome of interest following mechanical thrombectomy. In addition, Spearman rank order correlation was used to assess for r value between mRS and WBV at different shear rates.ResultsBaseline group characteristics, including demographics and medical history, were similar among the two study groups. Of note, our study found no significant differences in clinical outcomes between the two groups with WBV at high shear rate (OR 0.969, 95% CI 0.77–1.204, p = 0.780) and low shear rate (OR 0.998, 95% CI 0.988–1.008, p = 0.779) following mechanical thrombectomy. Spearman rank order correlation between mRS at discharge with WBV at high shear rate (r = 0.058, p = 0.123) and low shear rate (r = 0.048, p = 0.128) was non-significant.DiscussionThere is limited information of the effect of WBV at high and low shear rates on the clinical outcome following mechanical thrombectomy in patients with LVO. Our results revealed that WBV at high and low shear rates did not impact the functional outcome of mechanical thrombectomy. This result might be affected by the potential limitation of the formula used to derive the given shear rates. Despite this lack of association observed in our study, other contributors of viscosity may still potentially play a significant role in outcome following mechanical thrombectomy. |
| format | Article |
| id | doaj-art-a99c85389e154dffb1aa85a216ca3b4f |
| institution | DOAJ |
| issn | 2813-3056 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Stroke |
| spelling | doaj-art-a99c85389e154dffb1aa85a216ca3b4f2025-08-20T02:58:53ZengFrontiers Media S.A.Frontiers in Stroke2813-30562025-03-01410.3389/fstro.2025.15173431517343The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic strokeMonika Thapa0Jordyn Courville1Reese Leonhard2Prabandh Buchhanolla3Mohammad Abdurrehman Sheikh4Rahul Shah5Prashant Rai6Himanshu Chokhawala7Md Ismail Hossain8Mohammad Alfrad Nobel Bhuiyan9J. Dedrick Jordan10Roger E. Kelley11Department of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesBiostatistics and Computational Biology Laboratory, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, United StatesBiostatistics and Computational Biology Laboratory, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesDepartment of Neurology, Louisiana State University Health Shreveport, Shreveport, LA, United StatesIntroductionWhole blood viscosity (WBV), reflecting the intrinsic resistance of blood flow, is an established predictor of stroke events in individuals. This study aims to correlate the WBV at different shear rates with the outcome of mechanical thrombectomy, known to be an effective treatment for large vessel occlusion (LVO) stroke.MethodThis is a single-center retrospective study conducted at our comprehensive stroke center. The charts of 317 patients who underwent mechanical thrombectomy within 6 h of LVO stroke presentation were reviewed. The modified Rankin score (mRS) at discharge was used as the outcome measure, with individuals categorized as low (0–2) or high (3–6). WBV at different shear rates was calculated using De Simone's Formula. The T-test and Chi-square test were used to compare baseline continuous and categorical data, respectively, amongst the mRS study groups. We utilized multivariable logistic regression analyses to identify the independent risk factors associated with the outcome of interest following mechanical thrombectomy. In addition, Spearman rank order correlation was used to assess for r value between mRS and WBV at different shear rates.ResultsBaseline group characteristics, including demographics and medical history, were similar among the two study groups. Of note, our study found no significant differences in clinical outcomes between the two groups with WBV at high shear rate (OR 0.969, 95% CI 0.77–1.204, p = 0.780) and low shear rate (OR 0.998, 95% CI 0.988–1.008, p = 0.779) following mechanical thrombectomy. Spearman rank order correlation between mRS at discharge with WBV at high shear rate (r = 0.058, p = 0.123) and low shear rate (r = 0.048, p = 0.128) was non-significant.DiscussionThere is limited information of the effect of WBV at high and low shear rates on the clinical outcome following mechanical thrombectomy in patients with LVO. Our results revealed that WBV at high and low shear rates did not impact the functional outcome of mechanical thrombectomy. This result might be affected by the potential limitation of the formula used to derive the given shear rates. Despite this lack of association observed in our study, other contributors of viscosity may still potentially play a significant role in outcome following mechanical thrombectomy.https://www.frontiersin.org/articles/10.3389/fstro.2025.1517343/fullstrokeischemiathrombectomyviscositylarge vessel occlusionmodified Rankin score |
| spellingShingle | Monika Thapa Jordyn Courville Reese Leonhard Prabandh Buchhanolla Mohammad Abdurrehman Sheikh Rahul Shah Prashant Rai Himanshu Chokhawala Md Ismail Hossain Mohammad Alfrad Nobel Bhuiyan J. Dedrick Jordan Roger E. Kelley The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke Frontiers in Stroke stroke ischemia thrombectomy viscosity large vessel occlusion modified Rankin score |
| title | The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke |
| title_full | The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke |
| title_fullStr | The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke |
| title_full_unstemmed | The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke |
| title_short | The correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke |
| title_sort | correlation of whole blood viscosity and outcome in mechanical thrombectomy for acute ischemic stroke |
| topic | stroke ischemia thrombectomy viscosity large vessel occlusion modified Rankin score |
| url | https://www.frontiersin.org/articles/10.3389/fstro.2025.1517343/full |
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