Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model
Abstract Several lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive function and neuropathology in Alzheimer’s disease (AD). To test this possibility, full-length type I or type III NRG1 was overexpressed via lentiviral vectors in the hippocampus of line 41 AD mouse...
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| Main Authors: | Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/srep31692 |
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