Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels
Nanocomposite hydrogels based on poly(vinyl alcohol) – PVA and sepiolite have been prepared and their potential for drug delivery systems has been assessed by taking rifampicin as model drug. The nanocomposite hydrogels were characterized by WAXS and DSC and the swelling behavior and structural stab...
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| Format: | Article |
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| Language: | English |
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Budapest University of Technology and Economics
2009-08-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0000993&mi=cd |
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| collection | DOAJ |
| description | Nanocomposite hydrogels based on poly(vinyl alcohol) – PVA and sepiolite have been prepared and their potential for drug delivery systems has been assessed by taking rifampicin as model drug. The nanocomposite hydrogels were characterized by WAXS and DSC and the swelling behavior and structural stability were evaluated. The effect of the presence of rifampicin, sepiolite and simultaneous rifampicin-sepiolite on the structure and swelling of the hydrogels was investigated. The swelling data were analyzed in order to evaluate the diffusion mechanisms of water. The results indicate that both rifampicin and sepiolite cause important modifications on microstructure of the PVA matrix, leading to changes on swelling and diffusional behavior. |
| format | Article |
| id | doaj-art-a996777dcd964d4abdc834adbc295b32 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2009-08-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-a996777dcd964d4abdc834adbc295b322025-08-20T03:35:57ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2009-08-013851852410.3144/expresspolymlett.2009.64Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogelsNanocomposite hydrogels based on poly(vinyl alcohol) – PVA and sepiolite have been prepared and their potential for drug delivery systems has been assessed by taking rifampicin as model drug. The nanocomposite hydrogels were characterized by WAXS and DSC and the swelling behavior and structural stability were evaluated. The effect of the presence of rifampicin, sepiolite and simultaneous rifampicin-sepiolite on the structure and swelling of the hydrogels was investigated. The swelling data were analyzed in order to evaluate the diffusion mechanisms of water. The results indicate that both rifampicin and sepiolite cause important modifications on microstructure of the PVA matrix, leading to changes on swelling and diffusional behavior.http://www.expresspolymlett.com/letolt.php?file=EPL-0000993&mi=cdPolymer gelsHydrogelNanocompositeRifampicinPoly(vinyl alcohol) |
| spellingShingle | Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels eXPRESS Polymer Letters Polymer gels Hydrogel Nanocomposite Rifampicin Poly(vinyl alcohol) |
| title | Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels |
| title_full | Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels |
| title_fullStr | Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels |
| title_full_unstemmed | Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels |
| title_short | Effect of sepiolite on the physical properties and swelling behavior of rifampicin-loaded nanocomposite hydrogels |
| title_sort | effect of sepiolite on the physical properties and swelling behavior of rifampicin loaded nanocomposite hydrogels |
| topic | Polymer gels Hydrogel Nanocomposite Rifampicin Poly(vinyl alcohol) |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0000993&mi=cd |