Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.

Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.

<h4>Background</h4>The cross-talk between pathogenic T lymphocytes and regulatory T cells (Tregs) plays a major role in the progression of autoimmune diseases. Our objective is to identify molecules and/or pathways involved in this interaction and representing potential targets for innov...

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Main Authors: Sylvaine You, Lynn Poulton, Steve Cobbold, Chih-Pin Liu, Michael Rosenzweig, Douglas Ringler, Wen-Hui Lee, Berta Segovia, Jean-François Bach, Herman Waldmann, Lucienne Chatenoud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007848&type=printable
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