Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients
Combination of TB and HIV-infection is still the most nowadays important problem, and it connects not only with steady growth of HIV infection, but with difficulties in TB diagnosis. X-ray lung studies often have unusual nature, clinical symptomatology appears when process are hard and spread. At th...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2015-11-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/431 |
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| author | A. A. Starshinova A. M. Panteleev E. V. Vasil’eva V. V. Manina M. V. Pavlova N. V. Sapozhnikova |
| author_facet | A. A. Starshinova A. M. Panteleev E. V. Vasil’eva V. V. Manina M. V. Pavlova N. V. Sapozhnikova |
| author_sort | A. A. Starshinova |
| collection | DOAJ |
| description | Combination of TB and HIV-infection is still the most nowadays important problem, and it connects not only with steady growth of HIV infection, but with difficulties in TB diagnosis. X-ray lung studies often have unusual nature, clinical symptomatology appears when process are hard and spread. At the same time in global practice IGRAtests applying, to which they belong to SPOT.TB test and QuantiFERON®-TB Gold test, they pay great attention to it, particularly among patients with HIV- infection. In study there were data when 41 patients with lung TB were examined, 56 HIV-positive patients with lung TB and 58 healthy donors. When active TB IGRA-test and test with Diaskin test show comparable same results. Against the backdrop of HIV skin tests (Mantoux test with 2 TE and tests with Diaskin test) it was demonstrated direct dependence of level immunosuppression in contrast to IGRA – tests, that allows to carry out these researches in conditions when standard skin tests do not work. |
| format | Article |
| id | doaj-art-a9851390f013469eb72fbbcbdbee4695 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2015-11-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-a9851390f013469eb72fbbcbdbee46952025-08-20T03:44:24ZrusJournal InfectologyЖурнал инфектологии2072-67322015-11-017312613010.22625/2072-6732-2015-7-3-126-130435Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patientsA. A. Starshinova0A. M. Panteleev1E. V. Vasil’eva2V. V. Manina3M. V. Pavlova4N. V. Sapozhnikova5Saint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, RussiaCity Tuberculosis Hospital № 2, Saint-Petersburg, Russia First Saint-Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, RussiaSaint-Petersburg Scienсe Research Institute of Epidemiology and Microbiology named after Pasteur, Saint-Petersburg, RussiaSaint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, RussiaSaint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, RussiaSaint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, RussiaCombination of TB and HIV-infection is still the most nowadays important problem, and it connects not only with steady growth of HIV infection, but with difficulties in TB diagnosis. X-ray lung studies often have unusual nature, clinical symptomatology appears when process are hard and spread. At the same time in global practice IGRAtests applying, to which they belong to SPOT.TB test and QuantiFERON®-TB Gold test, they pay great attention to it, particularly among patients with HIV- infection. In study there were data when 41 patients with lung TB were examined, 56 HIV-positive patients with lung TB and 58 healthy donors. When active TB IGRA-test and test with Diaskin test show comparable same results. Against the backdrop of HIV skin tests (Mantoux test with 2 TE and tests with Diaskin test) it was demonstrated direct dependence of level immunosuppression in contrast to IGRA – tests, that allows to carry out these researches in conditions when standard skin tests do not work.https://journal.niidi.ru/jofin/article/view/431hivdiagnosisimmunologic methodsskin teststbigra-tests |
| spellingShingle | A. A. Starshinova A. M. Panteleev E. V. Vasil’eva V. V. Manina M. V. Pavlova N. V. Sapozhnikova Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients Журнал инфектологии hiv diagnosis immunologic methods skin tests tb igra-tests |
| title | Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients |
| title_full | Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients |
| title_fullStr | Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients |
| title_full_unstemmed | Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients |
| title_short | Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients |
| title_sort | application of modern immunological methods in the diagnosis of tuberculosis in hiv infected patients |
| topic | hiv diagnosis immunologic methods skin tests tb igra-tests |
| url | https://journal.niidi.ru/jofin/article/view/431 |
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