Role of the TGF-β/Smad3 pathway in pancreatic cancer cell growth and stem cell characteristics

Role of the TGF-β/Smad3 pathway in pancreatic cancer cell growth and stem cell characteristics

Abstract Pancreatic cancer (PC) is a highly malignant digestive system tumor with poor prognosis, and cancer stem cell (CSC) is known to drive its progression, metastasis, and recurrence. The transforming growth factor-β (TGF-β)/small mothers against decapentaplegic 3 (Smad3) signaling is implicated...

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Bibliographic Details
Main Authors: Yanling Zhang, Qianya Chen, Danna Chen, Guangda Yang
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Pancreatic cancer
Cancer stem cells
TGF-β/Smad3 pathway
Online Access:https://doi.org/10.1007/s12672-025-03220-9
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