Rational choice of eradication therapy of <i>Helicobacter pylori</i> infection
The aim of review. To present literature data on the most actual modes of Helicobacter pylori eradication therapy and tactics for their choice in various clinical situations.Key points. Following modes of H. pylori eradication therapy have the greatest practical value: standard triple therapy with c...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2013-10-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1234 |
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| Summary: | The aim of review. To present literature data on the most actual modes of Helicobacter pylori eradication therapy and tactics for their choice in various clinical situations.Key points. Following modes of H. pylori eradication therapy have the greatest practical value: standard triple therapy with clarithromycin, including proton pump inhibitor (PPI) + clarithromycin + amoxicillin (or metronidazole); sequential two-stage mode; four constituent component mode without bismuth drug; four-component mode including bismuth agent; triple therapy with PPI and levofloxacin. According to the Russian data, clarithromycin resistance of H. pylori ranges from 5 to 11% that allows to consider standard triple therapy as first line treatment. Quadrotherapy can be utilized as serves as alternative mode of the first line and the most justified mode in case of failure of standard triple therapy. Efficacy of sequential therapy mode and non-bismuth quadruple therapy requires more detailed studying in Russian studies.Conclusion. The rational choice and the justified sequence of modes of antihelicobacter therapy allow to achieve successful H. pylori eradication almost in all treated patients. |
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| ISSN: | 1382-4376 2658-6673 |