Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma
Abstract The present study investigated the Zinc finger BED-type containing 3 (ZBED3) mRNA expression levels, diagnostic and prognostic values, co-expressed and differentially expressed genes, immune infiltration, and functional enrichment analysis in patients with kidney renal clear cell carcinoma...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-77453-z |
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| author | Shaobo Wu Min Yang Qiurong Zhao Cheng Zhang Xiaohe Luo |
| author_facet | Shaobo Wu Min Yang Qiurong Zhao Cheng Zhang Xiaohe Luo |
| author_sort | Shaobo Wu |
| collection | DOAJ |
| description | Abstract The present study investigated the Zinc finger BED-type containing 3 (ZBED3) mRNA expression levels, diagnostic and prognostic values, co-expressed and differentially expressed genes, immune infiltration, and functional enrichment analysis in patients with kidney renal clear cell carcinoma (KIRC) using various public databases such as The Cancer Genome Atlas, Genotype-Tissue Expression Project, LinkedOmics, Gene Set Enrichment Analysis databases, and the Xiantao academic tool. Through extensive data mining, our study revealed differential expression of ZBED3 in various tumor and paired normal tissues. Specifically, ZBED3 expression was found to be significantly decreased in KIRC, particularly in advanced pathologic stages and histologic grades, when compared to corresponding control tissues. Our analysis revealed that the overexpression of ZBED3 is associated with a favorable overall survival outcome in KIRC patients. Moreover, functional enrichment analysis identified key pathways related to inflammation response and DNA methylation of ZBED3 in KIRC. Additionally, our findings suggest that the upregulation of ZBED3 leads to the inhibition of cell proliferation by modulating cell-cycle progression in KIRC cell lines. Taken together, these results suggest that ZBED3 may serve as a promising biomarker and prognostic indicator for individuals diagnosed with KIRC. |
| format | Article |
| id | doaj-art-a97b3afb8bb942b096f2d6e71cd3fcac |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-a97b3afb8bb942b096f2d6e71cd3fcac2025-08-20T02:13:31ZengNature PortfolioScientific Reports2045-23222024-11-0114111710.1038/s41598-024-77453-zIntegrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinomaShaobo Wu0Min Yang1Qiurong Zhao2Cheng Zhang3Xiaohe Luo4Department of Endocrinology, School of Medicine, Chongqing University Three Gorges Hospital, Chongqing UniversityDepartment of Laboratory Medicine, School of Medicine, Chongqing University Three Gorges Hospital, Chongqing UniversityDepartment of Central Laboratory, Chongqing University Three Gorges Hospital, Chongqing UniversityDepartment of Endocrinology, School of Medicine, Chongqing University Three Gorges Hospital, Chongqing UniversityDepartment of Laboratory Medicine, School of Medicine, Chongqing University Three Gorges Hospital, Chongqing UniversityAbstract The present study investigated the Zinc finger BED-type containing 3 (ZBED3) mRNA expression levels, diagnostic and prognostic values, co-expressed and differentially expressed genes, immune infiltration, and functional enrichment analysis in patients with kidney renal clear cell carcinoma (KIRC) using various public databases such as The Cancer Genome Atlas, Genotype-Tissue Expression Project, LinkedOmics, Gene Set Enrichment Analysis databases, and the Xiantao academic tool. Through extensive data mining, our study revealed differential expression of ZBED3 in various tumor and paired normal tissues. Specifically, ZBED3 expression was found to be significantly decreased in KIRC, particularly in advanced pathologic stages and histologic grades, when compared to corresponding control tissues. Our analysis revealed that the overexpression of ZBED3 is associated with a favorable overall survival outcome in KIRC patients. Moreover, functional enrichment analysis identified key pathways related to inflammation response and DNA methylation of ZBED3 in KIRC. Additionally, our findings suggest that the upregulation of ZBED3 leads to the inhibition of cell proliferation by modulating cell-cycle progression in KIRC cell lines. Taken together, these results suggest that ZBED3 may serve as a promising biomarker and prognostic indicator for individuals diagnosed with KIRC.https://doi.org/10.1038/s41598-024-77453-zPan-cancerKidney renal clear cell carcinomaZBED3Integrative analysis |
| spellingShingle | Shaobo Wu Min Yang Qiurong Zhao Cheng Zhang Xiaohe Luo Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma Scientific Reports Pan-cancer Kidney renal clear cell carcinoma ZBED3 Integrative analysis |
| title | Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma |
| title_full | Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma |
| title_fullStr | Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma |
| title_full_unstemmed | Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma |
| title_short | Integrated pan-cancer analysis and experimental verification of the roles of ZBED3 in kidney renal clear cell carcinoma |
| title_sort | integrated pan cancer analysis and experimental verification of the roles of zbed3 in kidney renal clear cell carcinoma |
| topic | Pan-cancer Kidney renal clear cell carcinoma ZBED3 Integrative analysis |
| url | https://doi.org/10.1038/s41598-024-77453-z |
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