Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review
Two cases of fulminant pulmonary legionellosis, complicated by prolonged intensive care unit stays and acute respiratory distress syndrome, and who were recently treated with infliximab for Crohn’s disease, are described. A review of the literature revealed three additional cases in patients with in...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2009/836938 |
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| _version_ | 1849397020110880768 |
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| author | Adam Hofmann Yanick Beaulieu Francis Bernard Philippe Rico |
| author_facet | Adam Hofmann Yanick Beaulieu Francis Bernard Philippe Rico |
| author_sort | Adam Hofmann |
| collection | DOAJ |
| description | Two cases of fulminant pulmonary legionellosis, complicated by prolonged intensive care unit stays and acute respiratory distress syndrome, and who were recently treated with infliximab for Crohn’s disease, are described. A review of the literature revealed three additional cases in patients with inflammatory bowel disease, and a total of 22 cases of Legionella pneumophila pneumonia in the context of treatment with antitumour necrosis (TNF)-alpha medications. The median age of the patients was 49 years, and men and women were affected equally. The case fatality rate was 14% (three of 22). Early recognition and treatment of this anti-TNF-alpha-related complication would likely result in reduced mortality and morbidity. Physicians prescribing anti-TNF-alpha drugs should be aware of this association. |
| format | Article |
| id | doaj-art-a977e02b92864773a14e1994faa9cd73 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-a977e02b92864773a14e1994faa9cd732025-08-20T03:39:10ZengWileyCanadian Journal of Gastroenterology0835-79002009-01-01231282983310.1155/2009/836938Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature ReviewAdam Hofmann0Yanick Beaulieu1Francis Bernard2Philippe Rico3Department of General Internal Medicine, McGill University Faculty of Medicine, Montreal, Quebec, CanadaDepartment of Cardiology and Critical Care, Hôpital Sacré-Cœur, Montreal University, Montreal, Quebec, CanadaDepartment of Internal Medicine and Critical Care, Hôpital Sacré-Cœur, Montreal University, Montreal, Quebec, CanadaDepartment of Internal Medicine and Critical Care, Hôpital Sacré-Cœur, Montreal University, Montreal, Quebec, CanadaTwo cases of fulminant pulmonary legionellosis, complicated by prolonged intensive care unit stays and acute respiratory distress syndrome, and who were recently treated with infliximab for Crohn’s disease, are described. A review of the literature revealed three additional cases in patients with inflammatory bowel disease, and a total of 22 cases of Legionella pneumophila pneumonia in the context of treatment with antitumour necrosis (TNF)-alpha medications. The median age of the patients was 49 years, and men and women were affected equally. The case fatality rate was 14% (three of 22). Early recognition and treatment of this anti-TNF-alpha-related complication would likely result in reduced mortality and morbidity. Physicians prescribing anti-TNF-alpha drugs should be aware of this association.http://dx.doi.org/10.1155/2009/836938 |
| spellingShingle | Adam Hofmann Yanick Beaulieu Francis Bernard Philippe Rico Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review Canadian Journal of Gastroenterology |
| title | Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review |
| title_full | Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review |
| title_fullStr | Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review |
| title_full_unstemmed | Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review |
| title_short | Fulminant Legionellosis in Two Patients Treated with Infliximab for Crohn’s Disease: Case Series and Literature Review |
| title_sort | fulminant legionellosis in two patients treated with infliximab for crohn s disease case series and literature review |
| url | http://dx.doi.org/10.1155/2009/836938 |
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