Biomarker-Driven Pharmacokinetics and Efficacy of Polymyxin B in Critically Ill Patients with XDR-GN Pneumonia

Biomarker-Driven Pharmacokinetics and Efficacy of Polymyxin B in Critically Ill Patients with XDR-GN Pneumonia

<b>Background:</b> Achieving pharmacokinetic/pharmacodynamic (PK/PD) targets is critical for improving treatment success, particularly in critically ill patients. This study investigates the role of inflammatory biomarkers and their influence on the PK/PD characteristics of polymyxin B (...

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Bibliographic Details
Main Authors: Wei Zuo, Qianlin Wang, Longxiang Su, Jiaxin Yu, Hongwei Fan, Qiang Fu, Yun Long, Bo Zhang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
polymyxin B
pharmacokinetic and pharmacodynamics
bronchoalveolar lavage fluid
inflammatory factors
Online Access:https://www.mdpi.com/1424-8247/18/4/586
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