Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis
Purpose. To study the protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis (SAP). Methods. The SAP rats were randomly assigned to the model group and dexamethasone-treated group, the other normal healthy rats were assigned to the sham operation group. The rat...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/72361 |
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| _version_ | 1850160502925164544 |
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| author | Zhang Xiping Chen Li Lin Miao Tian Hua |
| author_facet | Zhang Xiping Chen Li Lin Miao Tian Hua |
| author_sort | Zhang Xiping |
| collection | DOAJ |
| description | Purpose. To study the protecting effects of dexamethasone on thymus of rats with
severe acute pancreatitis (SAP).
Methods. The SAP rats were randomly assigned to the model group and
dexamethasone-treated group, the other normal healthy rats were assigned to the sham operation
group. The rat survival, thymus pathological changes, apoptotic index, as well as expression
levels of NF-κB, P-selectin, Bax, Bcl-2, and Caspase-3 protein of all groups were
observed, respectively, at 3 hours, 6 hours, and 12 hours. The contents of amylase and endotoxin in plasma
as well as the contents of TNF-α, PLA2, and NO in serum were determined.
Results. There was no marked difference between the model group and treated group
in survival. The contents of different indexes in blood of treated group were lower than those of the model
group to various degrees at different time points. The thymus pathological score was lower in treated group
than in model group at 12 hours.The treated group in Caspase-3 protein expression of thymus significantly
exceeded the model group at 12 hours. The apoptotic index was significantly higher in treated group than
in model group. Conclusion. Dexamethasone has protecting effects on thymus of SAP
rats. |
| format | Article |
| id | doaj-art-a9742260cd9241bfa1aea17ff1f46b90 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a9742260cd9241bfa1aea17ff1f46b902025-08-20T02:23:08ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/7236172361Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute PancreatitisZhang Xiping0Chen Li1Lin Miao2Tian Hua3Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaDepartment of General Surgery, Second Affiliated Hospital Medical College, Hangzhou, Zhejiang Province 310003, ChinaZhejiang University of Traditional Chinese Medical, Hangzhou 310053, Zhejiang Province, ChinaDepartment of General Surgery, Second Affiliated Hospital Medical College, Hangzhou, Zhejiang Province 310003, ChinaPurpose. To study the protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis (SAP). Methods. The SAP rats were randomly assigned to the model group and dexamethasone-treated group, the other normal healthy rats were assigned to the sham operation group. The rat survival, thymus pathological changes, apoptotic index, as well as expression levels of NF-κB, P-selectin, Bax, Bcl-2, and Caspase-3 protein of all groups were observed, respectively, at 3 hours, 6 hours, and 12 hours. The contents of amylase and endotoxin in plasma as well as the contents of TNF-α, PLA2, and NO in serum were determined. Results. There was no marked difference between the model group and treated group in survival. The contents of different indexes in blood of treated group were lower than those of the model group to various degrees at different time points. The thymus pathological score was lower in treated group than in model group at 12 hours.The treated group in Caspase-3 protein expression of thymus significantly exceeded the model group at 12 hours. The apoptotic index was significantly higher in treated group than in model group. Conclusion. Dexamethasone has protecting effects on thymus of SAP rats.http://dx.doi.org/10.1155/2007/72361 |
| spellingShingle | Zhang Xiping Chen Li Lin Miao Tian Hua Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis Mediators of Inflammation |
| title | Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis |
| title_full | Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis |
| title_fullStr | Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis |
| title_full_unstemmed | Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis |
| title_short | Protecting Effects of Dexamethasone on Thymus of Rats with Severe Acute Pancreatitis |
| title_sort | protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis |
| url | http://dx.doi.org/10.1155/2007/72361 |
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