Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy
The incidence of chronic kidney disease （CKD） has been rising yearly. And it has become one of the major hazards to public health in the world. The underlying causes of CKD include primary/secondary glomerulonephritis， diabetic nephropathy， hypertensive renal damage， renal tubulointerstitial lesions...
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Editorial Department of Journal of Clinical Nephrology
2022-07-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.07.011 |
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| author | Deng Xuan Wang Yu |
| author_facet | Deng Xuan Wang Yu |
| author_sort | Deng Xuan |
| collection | DOAJ |
| description | The incidence of chronic kidney disease （CKD） has been rising yearly. And it has become one of the major hazards to public health in the world. The underlying causes of CKD include primary/secondary glomerulonephritis， diabetic nephropathy， hypertensive renal damage， renal tubulointerstitial lesions and genetic disorder， etc. Diabetic kidney disease （DKD）， one of the causes of CKD， is a complication of diabetic renal microangiopathy and end-stage renal disease ensues if left unchecked. The specific pathogenesis of DKD has remained elusive. Hyperglycemia causes immune-mediated inflammation and renal injuries. However， immune-mediated inflammatory factors are one of the important causes of DKD. During hyperglycemia， such inflammatory response cells as interleukin and tumor necrosis factors are mobilized to infiltrate kidney and stimulate the development of renal microangiopathy through a large variety of signaling pathways. In recent years， Toll-like receptor 4 （TLR4） and NoD-like receptor family pyrin domain-containing protein 3 （NLRP3） play an important role in renal-related immune inflammatory diseases. And TLR4/NLRP3 inflammatory bodies are closely correlated with the pathogenesis of DKD. Elevated TLR4 level has been detected under hyperglycemia. However， TLR4 stimulates the maturation and release of downstream inflammatory factors by activating NF-κB through recognizing specific ligands and NLRP3 inflammatory bodies exist sparsely in mesangial cells of DKD. The activation of NF-κB activates the assembly and maturation of inflammatory bodies， thus promoting the release of inflammatory cytokines. Thus TLR4 and NLRP3 play some important roles in the development of diabetic nephropathy. |
| format | Article |
| id | doaj-art-a972ec86c8424bed8edcd67aeb3d6905 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-07-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-a972ec86c8424bed8edcd67aeb3d69052025-08-20T03:53:07ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-07-012259560128887562Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathyDeng XuanWang YuThe incidence of chronic kidney disease （CKD） has been rising yearly. And it has become one of the major hazards to public health in the world. The underlying causes of CKD include primary/secondary glomerulonephritis， diabetic nephropathy， hypertensive renal damage， renal tubulointerstitial lesions and genetic disorder， etc. Diabetic kidney disease （DKD）， one of the causes of CKD， is a complication of diabetic renal microangiopathy and end-stage renal disease ensues if left unchecked. The specific pathogenesis of DKD has remained elusive. Hyperglycemia causes immune-mediated inflammation and renal injuries. However， immune-mediated inflammatory factors are one of the important causes of DKD. During hyperglycemia， such inflammatory response cells as interleukin and tumor necrosis factors are mobilized to infiltrate kidney and stimulate the development of renal microangiopathy through a large variety of signaling pathways. In recent years， Toll-like receptor 4 （TLR4） and NoD-like receptor family pyrin domain-containing protein 3 （NLRP3） play an important role in renal-related immune inflammatory diseases. And TLR4/NLRP3 inflammatory bodies are closely correlated with the pathogenesis of DKD. Elevated TLR4 level has been detected under hyperglycemia. However， TLR4 stimulates the maturation and release of downstream inflammatory factors by activating NF-κB through recognizing specific ligands and NLRP3 inflammatory bodies exist sparsely in mesangial cells of DKD. The activation of NF-κB activates the assembly and maturation of inflammatory bodies， thus promoting the release of inflammatory cytokines. Thus TLR4 and NLRP3 play some important roles in the development of diabetic nephropathy.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.07.011Chronic kidney diseaseDiabetic kidney diseaseToll-Like Receptor 4Nod-like receptor family pyrin domain-containing protein 3 |
| spellingShingle | Deng Xuan Wang Yu Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy Linchuang shenzangbing zazhi Chronic kidney disease Diabetic kidney disease Toll-Like Receptor 4 Nod-like receptor family pyrin domain-containing protein 3 |
| title | Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy |
| title_full | Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy |
| title_fullStr | Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy |
| title_full_unstemmed | Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy |
| title_short | Research advances of role of TLR4/NLRP3 inflammasome in diabetic nephropathy |
| title_sort | research advances of role of tlr4 nlrp3 inflammasome in diabetic nephropathy |
| topic | Chronic kidney disease Diabetic kidney disease Toll-Like Receptor 4 Nod-like receptor family pyrin domain-containing protein 3 |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.07.011 |
| work_keys_str_mv | AT dengxuan researchadvancesofroleoftlr4nlrp3inflammasomeindiabeticnephropathy AT wangyu researchadvancesofroleoftlr4nlrp3inflammasomeindiabeticnephropathy |