Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs
Abstract The prevalence of obesity in dogs is increasing worldwide. This study evaluated the effects of a mixed probiotic formula on the weight, body condition score (BCS), blood metabolite profiles, and gut microbiota of overweight and obese dogs over a 12-week supplementation period to determine t...
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Nature Portfolio
2024-10-01
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| Online Access: | https://doi.org/10.1038/s41598-024-75594-9 |
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| author | Jihee Choi Dooheon Son Subin An Eunbee Cho Sanghyun Lim Hae-Jeung Lee |
| author_facet | Jihee Choi Dooheon Son Subin An Eunbee Cho Sanghyun Lim Hae-Jeung Lee |
| author_sort | Jihee Choi |
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| description | Abstract The prevalence of obesity in dogs is increasing worldwide. This study evaluated the effects of a mixed probiotic formula on the weight, body condition score (BCS), blood metabolite profiles, and gut microbiota of overweight and obese dogs over a 12-week supplementation period to determine the anti-obesity effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3. This was a community-based, randomized study that sampled 41 overweight and obese dogs with a veterinarian-determined BCS of 6 or more. The physical activity of all the subjects was measured using a pedometer designed exclusively for dogs. The food intake was measured using the developed application. Only the treatment group received the mixed probiotic formula twice daily (3 g per dose). A significant decrease in body weight (p < 0.0001), BCS (p < 0.0001), serum TG (p < 0.0001), serum TC (p = 0.0400), and serum leptin (p = 0.0252), and a significantly increased serum adiponectin levels (p = 0.0007) were observed in the treatment group compared with the values in the control group. Microbiota analysis showed that Lactiplantibacillus increased and Erysipelatoclostridium, Staphylococcus, and Gemella decreased more significantly in the treatment group than in the control group. These results suggested that Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 may be effective in alleviating obesity in dogs. |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
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| spelling | doaj-art-a96b3c5fffd5482e9bd0cb7df3ece3072025-08-20T03:04:50ZengNature PortfolioScientific Reports2045-23222024-10-0114111810.1038/s41598-024-75594-9Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogsJihee Choi0Dooheon Son1Subin An2Eunbee Cho3Sanghyun Lim4Hae-Jeung Lee5Department of Food and Nutrition, College of Bionanotechnology, Gachon UniversityR&D Center, Cell Biotech Co. Ltd.Department of Food and Nutrition, College of Bionanotechnology, Gachon UniversityR&D Center, Cell Biotech Co. Ltd.R&D Center, Cell Biotech Co. Ltd.Department of Food and Nutrition, College of Bionanotechnology, Gachon UniversityAbstract The prevalence of obesity in dogs is increasing worldwide. This study evaluated the effects of a mixed probiotic formula on the weight, body condition score (BCS), blood metabolite profiles, and gut microbiota of overweight and obese dogs over a 12-week supplementation period to determine the anti-obesity effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3. This was a community-based, randomized study that sampled 41 overweight and obese dogs with a veterinarian-determined BCS of 6 or more. The physical activity of all the subjects was measured using a pedometer designed exclusively for dogs. The food intake was measured using the developed application. Only the treatment group received the mixed probiotic formula twice daily (3 g per dose). A significant decrease in body weight (p < 0.0001), BCS (p < 0.0001), serum TG (p < 0.0001), serum TC (p = 0.0400), and serum leptin (p = 0.0252), and a significantly increased serum adiponectin levels (p = 0.0007) were observed in the treatment group compared with the values in the control group. Microbiota analysis showed that Lactiplantibacillus increased and Erysipelatoclostridium, Staphylococcus, and Gemella decreased more significantly in the treatment group than in the control group. These results suggested that Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 may be effective in alleviating obesity in dogs.https://doi.org/10.1038/s41598-024-75594-9ObesityLactiplantibacillus plantarum CBT LP3Bifidobacterium breve CBT BR3WeightGut microbiotaDog |
| spellingShingle | Jihee Choi Dooheon Son Subin An Eunbee Cho Sanghyun Lim Hae-Jeung Lee Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs Scientific Reports Obesity Lactiplantibacillus plantarum CBT LP3 Bifidobacterium breve CBT BR3 Weight Gut microbiota Dog |
| title | Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs |
| title_full | Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs |
| title_fullStr | Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs |
| title_full_unstemmed | Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs |
| title_short | Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs |
| title_sort | effects of lactiplantibacillus plantarum cbt lp3 and bifidobacterium breve cbt br3 supplementation on weight loss and gut microbiota of overweight dogs |
| topic | Obesity Lactiplantibacillus plantarum CBT LP3 Bifidobacterium breve CBT BR3 Weight Gut microbiota Dog |
| url | https://doi.org/10.1038/s41598-024-75594-9 |
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