EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming

EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming

BackgroundClear cell renal cell carcinoma (ccRCC) is a prevalent and highly aggressive subtype of renal cancer. EPHX2, a metabolic regulator with tumor-suppressive properties, not only influences cell cycle dynamics but also interacts with multiple signaling pathways to inhibit tumor growth. However...

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Bibliographic Details
Main Authors: Bo Guan, Cong Huang, Jun He, Weimin Shan, Di Cui, Xiaowei Li, Chaozhao Liang, Zongyao Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
ccRCC
EPHX2
lipid metabolism
reprogramming
prognostic marker
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1541429/full
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