Genomic landscape of childhood acute lymphoblastic leukemia in Malaysia: insights from array-CGH

Genomic landscape of childhood acute lymphoblastic leukemia in Malaysia: insights from array-CGH

Abstract Background Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, comprising approximately 25% of pediatric malignancies. Notably, chromosomal aberrations and genetic alterations play a central role in the pathogenesis of ALL, serving as critical diagnostic and prognostic m...

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Main Authors: Azli Ismail, Fadly Ahid, Wong Nyuk Moi, Nor Rizan Kamaluddin, Ezalia Esa, Yuslina Mat Yusoff, Zahidah Abu Seman, Muhammad Asyraff Mohammed, Elizabeth George, Asmida Isa, Zubaidah Zakaria
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Cytogenetics
Subjects:
Array-based comparative genomic hybridization
Childhood acute lymphoblastic leukemia
Copy number variations
Variants of uncertain significance
Online Access:https://doi.org/10.1186/s13039-025-00709-4
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