Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx. Recent studies show that T-bet and Th1-associated factors are critical in regulating tumor development. However, the contributions o...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/949821 |
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| author | Yan Xu Jingjing Gao Zhaoliang Su Xiaoli Dai Yazhen Li Yingzhao Liu Jianguo Chen Jia Tong Yun Zhang Chaoyang Wu Dong Zheng Shengjun Wang Huaxi Xu |
| author_facet | Yan Xu Jingjing Gao Zhaoliang Su Xiaoli Dai Yazhen Li Yingzhao Liu Jianguo Chen Jia Tong Yun Zhang Chaoyang Wu Dong Zheng Shengjun Wang Huaxi Xu |
| author_sort | Yan Xu |
| collection | DOAJ |
| description | T-bet
plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx. Recent studies show that T-bet and Th1-associated factors are critical in regulating tumor development. However, the contributions of Hlx in the occurrence and development of cancer remain unknown. In this study, the Hlx, T-bet, Runx3, and IFN-γ were measured in PBMC from patients with gastric cancer and the correlation between Hlx and T-bet or IFN-γ was assessed. The expression levels of Hlx, T-bet, and IFN-γwere significantly decreased, and there was a positive correlation between Hlx and T-bet or IFN-γ. In addition, the Runx3 expression was also downregulated with the lower T-bet mRNA level. These results suggested that the decreased Hlx expression was closely associated with T-bet and Runx3 downregulations and may contribute to the development of gastric cancer. |
| format | Article |
| id | doaj-art-a9698cb91cb146e4814cfb1b08bf5097 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a9698cb91cb146e4814cfb1b08bf50972025-02-03T01:12:04ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/949821949821Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2Yan Xu0Jingjing Gao1Zhaoliang Su2Xiaoli Dai3Yazhen Li4Yingzhao Liu5Jianguo Chen6Jia Tong7Yun Zhang8Chaoyang Wu9Dong Zheng10Shengjun Wang11Huaxi Xu12Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212001, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212001, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212001, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, ChinaT-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx. Recent studies show that T-bet and Th1-associated factors are critical in regulating tumor development. However, the contributions of Hlx in the occurrence and development of cancer remain unknown. In this study, the Hlx, T-bet, Runx3, and IFN-γ were measured in PBMC from patients with gastric cancer and the correlation between Hlx and T-bet or IFN-γ was assessed. The expression levels of Hlx, T-bet, and IFN-γwere significantly decreased, and there was a positive correlation between Hlx and T-bet or IFN-γ. In addition, the Runx3 expression was also downregulated with the lower T-bet mRNA level. These results suggested that the decreased Hlx expression was closely associated with T-bet and Runx3 downregulations and may contribute to the development of gastric cancer.http://dx.doi.org/10.1155/2012/949821 |
| spellingShingle | Yan Xu Jingjing Gao Zhaoliang Su Xiaoli Dai Yazhen Li Yingzhao Liu Jianguo Chen Jia Tong Yun Zhang Chaoyang Wu Dong Zheng Shengjun Wang Huaxi Xu Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2 Clinical and Developmental Immunology |
| title | Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2 |
| title_full | Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2 |
| title_fullStr | Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2 |
| title_full_unstemmed | Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2 |
| title_short | Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2 |
| title_sort | downregulation of hlx closely related to the decreased expressions of t bet and runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of th1 th2 |
| url | http://dx.doi.org/10.1155/2012/949821 |
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