Cellular functions and biomedical applications of circular RNAs
Circular RNAs (circRNAs) have emerged as a large class of stable and conserved RNAs that are derived primarily from back-splicing of pre-mRNAs and expressed in a cell- and tissue-specific fashion. Recent studies have indicated that a subset...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-12-01
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| Series: | Acta Biochimica et Biophysica Sinica |
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| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024241 |
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| author | Zhang Zheyu Wang Zefeng |
| author_facet | Zhang Zheyu Wang Zefeng |
| author_sort | Zhang Zheyu |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) have emerged as a large class of stable and conserved RNAs that are derived primarily from back-splicing of pre-mRNAs and expressed in a cell- and tissue-specific fashion. Recent studies have indicated that a subset of circRNAs may undergo translation through cap-independent pathways mediated by internal ribosome entry sites (IRESs), m6A modifications, or IRES-like short elements. Considering the stability and low immunogenicity of circRNAs, in vitro transcribed circRNAs hold great promise in biomedical applications. In this review, we briefly discuss the noncoding and coding functions of circRNAs in cells, as well as the methods for the in vitro synthesis of circRNAs and current advances in the applications of circRNAs in biomedicine. |
| format | Article |
| id | doaj-art-a9649b6b9811482583c026d6ae2b806f |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-a9649b6b9811482583c026d6ae2b806f2025-01-24T00:56:48ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-12-015715716810.3724/abbs.202424120d259ccCellular functions and biomedical applications of circular RNAsZhang Zheyu0Wang Zefeng1["CAS Key Laboratory of Computational Biology, Biomed Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China"]["Shool of Life Science, Southern University of Science and Technology, Shenzhen 518055, China"]Circular RNAs (circRNAs) have emerged as a large class of stable and conserved RNAs that are derived primarily from back-splicing of pre-mRNAs and expressed in a cell- and tissue-specific fashion. Recent studies have indicated that a subset of circRNAs may undergo translation through cap-independent pathways mediated by internal ribosome entry sites (IRESs), m6A modifications, or IRES-like short elements. Considering the stability and low immunogenicity of circRNAs, in vitro transcribed circRNAs hold great promise in biomedical applications. In this review, we briefly discuss the noncoding and coding functions of circRNAs in cells, as well as the methods for the in vitro synthesis of circRNAs and current advances in the applications of circRNAs in biomedicine.https://www.sciengine.com/doi/10.3724/abbs.2024241circRNAcircRNA translationcircRNA synthesiscircRNA deliverycircRNA biomedical applications. |
| spellingShingle | Zhang Zheyu Wang Zefeng Cellular functions and biomedical applications of circular RNAs Acta Biochimica et Biophysica Sinica circRNA circRNA translation circRNA synthesis circRNA delivery circRNA biomedical applications. |
| title | Cellular functions and biomedical applications of circular RNAs |
| title_full | Cellular functions and biomedical applications of circular RNAs |
| title_fullStr | Cellular functions and biomedical applications of circular RNAs |
| title_full_unstemmed | Cellular functions and biomedical applications of circular RNAs |
| title_short | Cellular functions and biomedical applications of circular RNAs |
| title_sort | cellular functions and biomedical applications of circular rnas |
| topic | circRNA circRNA translation circRNA synthesis circRNA delivery circRNA biomedical applications. |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024241 |
| work_keys_str_mv | AT zhangzheyu cellularfunctionsandbiomedicalapplicationsofcircularrnas AT wangzefeng cellularfunctionsandbiomedicalapplicationsofcircularrnas |