Cellular functions and biomedical applications of circular RNAs

Circular RNAs (circRNAs) have emerged as a large class of stable and conserved RNAs that are derived primarily from back-splicing of pre-mRNAs and expressed in a cell- and tissue-specific fashion. Recent studies have indicated that a subset...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhang Zheyu, Wang Zefeng
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024241
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832590350888206336
author Zhang Zheyu
Wang Zefeng
author_facet Zhang Zheyu
Wang Zefeng
author_sort Zhang Zheyu
collection DOAJ
description Circular RNAs (circRNAs) have emerged as a large class of stable and conserved RNAs that are derived primarily from back-splicing of pre-mRNAs and expressed in a cell- and tissue-specific fashion. Recent studies have indicated that a subset of circRNAs may undergo translation through cap-independent pathways mediated by internal ribosome entry sites (IRESs), m6A modifications, or IRES-like short elements. Considering the stability and low immunogenicity of circRNAs, in vitro transcribed circRNAs hold great promise in biomedical applications. In this review, we briefly discuss the noncoding and coding functions of circRNAs in cells, as well as the methods for the in vitro synthesis of circRNAs and current advances in the applications of circRNAs in biomedicine.
format Article
id doaj-art-a9649b6b9811482583c026d6ae2b806f
institution Kabale University
issn 1672-9145
language English
publishDate 2024-12-01
publisher China Science Publishing & Media Ltd.
record_format Article
series Acta Biochimica et Biophysica Sinica
spelling doaj-art-a9649b6b9811482583c026d6ae2b806f2025-01-24T00:56:48ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-12-015715716810.3724/abbs.202424120d259ccCellular functions and biomedical applications of circular RNAsZhang Zheyu0Wang Zefeng1["CAS Key Laboratory of Computational Biology, Biomed Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China"]["Shool of Life Science, Southern University of Science and Technology, Shenzhen 518055, China"]Circular RNAs (circRNAs) have emerged as a large class of stable and conserved RNAs that are derived primarily from back-splicing of pre-mRNAs and expressed in a cell- and tissue-specific fashion. Recent studies have indicated that a subset of circRNAs may undergo translation through cap-independent pathways mediated by internal ribosome entry sites (IRESs), m6A modifications, or IRES-like short elements. Considering the stability and low immunogenicity of circRNAs, in vitro transcribed circRNAs hold great promise in biomedical applications. In this review, we briefly discuss the noncoding and coding functions of circRNAs in cells, as well as the methods for the in vitro synthesis of circRNAs and current advances in the applications of circRNAs in biomedicine.https://www.sciengine.com/doi/10.3724/abbs.2024241circRNAcircRNA translationcircRNA synthesiscircRNA deliverycircRNA biomedical applications.
spellingShingle Zhang Zheyu
Wang Zefeng
Cellular functions and biomedical applications of circular RNAs
Acta Biochimica et Biophysica Sinica
circRNA
circRNA translation
circRNA synthesis
circRNA delivery
circRNA biomedical applications.
title Cellular functions and biomedical applications of circular RNAs
title_full Cellular functions and biomedical applications of circular RNAs
title_fullStr Cellular functions and biomedical applications of circular RNAs
title_full_unstemmed Cellular functions and biomedical applications of circular RNAs
title_short Cellular functions and biomedical applications of circular RNAs
title_sort cellular functions and biomedical applications of circular rnas
topic circRNA
circRNA translation
circRNA synthesis
circRNA delivery
circRNA biomedical applications.
url https://www.sciengine.com/doi/10.3724/abbs.2024241
work_keys_str_mv AT zhangzheyu cellularfunctionsandbiomedicalapplicationsofcircularrnas
AT wangzefeng cellularfunctionsandbiomedicalapplicationsofcircularrnas