Coconut: covariate-assisted composite null hypothesis testing with applications to replicability analysis of high-throughput experimental data
Abstract Background Multiple testing of composite null hypotheses is critical for identifying simultaneous signals across studies. While it is common to incorporate external information in simple null hypotheses, exploiting such auxiliary covariates to provide prior structural relationships among co...
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| Main Authors: | Yan Li, Yanmei Li, Han Ma, Zitong Yue, Xin Zhang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12859-025-06163-8 |
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