Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients
Purpose: To evaluate the variability of oncogenic risk related to radiation exposure in patients frequently exposed to ionizing radiation for diagnostic purposes, specifically ICU patients, according to different risk models, including the BEIR VII, ICRP 103, and US EPA models. Methods: This was an...
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MDPI AG
2025-04-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/11/4/42 |
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| author | Emilio Quaia Chiara Zanon Riccardo Torchio Fabrizio Dughiero Francesca De Monte Marta Paiusco |
| author_facet | Emilio Quaia Chiara Zanon Riccardo Torchio Fabrizio Dughiero Francesca De Monte Marta Paiusco |
| author_sort | Emilio Quaia |
| collection | DOAJ |
| description | Purpose: To evaluate the variability of oncogenic risk related to radiation exposure in patients frequently exposed to ionizing radiation for diagnostic purposes, specifically ICU patients, according to different risk models, including the BEIR VII, ICRP 103, and US EPA models. Methods: This was an IRB-approved observational retrospective study. A total of 71 patients (58 male, 13 female; median age, 66 years; interquartile range [IQR], 65–71 years) admitted to the ICU who underwent X-ray examinations between 1 October 2021 and 28 February 2023 were included. For each patient, the cumulative effective dose during a single hospital admission was calculated. Lifetime attributable risk (LAR) was estimated based on the BEIR VII, ICRP 103, and US EPA risk models to calculate additional oncogenic risk related to radiation exposure. The Friedman test for repeated-measures analysis of variance was used to compare risk values between different models. The intraclass correlation coefficient (ICC) was used to assess the consistency of risk values between different models. Results: Different organ, leukemia, and all-cancer risk values estimated according to different oncogenic risk models were significantly different, but the intraclass correlation coefficient revealed a good (>0.75) or even excellent (>0.9) agreement between different risk models. The ICRP 103 model estimated a lower all-cancer (median 69.05 [IQR 30.35–195.37]) and leukemia risk (8.22 [3.02–27.93]) compared to the US EPA (all-cancer: 139.68 [50.51–416.16]; leukemia: 23.34 [3.47–64.37]) and BEIR VII (all-cancer: 162.08 [70.6–371.40]; leukemia: 24.66 [12.9–58.8]) models. Conclusions: Cancer risk values were significantly different between risk models, though inter-model agreement in the consistency of risk values was found to be good, or even excellent. |
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| issn | 2379-1381 2379-139X |
| language | English |
| publishDate | 2025-04-01 |
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| series | Tomography |
| spelling | doaj-art-a95ae35b2e3d4bea89a4f6608a04000b2025-08-20T02:25:07ZengMDPI AGTomography2379-13812379-139X2025-04-011144210.3390/tomography11040042Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit PatientsEmilio Quaia0Chiara Zanon1Riccardo Torchio2Fabrizio Dughiero3Francesca De Monte4Marta Paiusco5Department of Radiology, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Radiology, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Information Engineering, University of Padova, 35128 Padova, ItalyDepartment of Information Engineering, University of Padova, 35128 Padova, ItalyMedical Physics Department, Veneto Institute of Oncology IOV—IRCCS, 35128 Padova, ItalyMedical Physics Department, Veneto Institute of Oncology IOV—IRCCS, 35128 Padova, ItalyPurpose: To evaluate the variability of oncogenic risk related to radiation exposure in patients frequently exposed to ionizing radiation for diagnostic purposes, specifically ICU patients, according to different risk models, including the BEIR VII, ICRP 103, and US EPA models. Methods: This was an IRB-approved observational retrospective study. A total of 71 patients (58 male, 13 female; median age, 66 years; interquartile range [IQR], 65–71 years) admitted to the ICU who underwent X-ray examinations between 1 October 2021 and 28 February 2023 were included. For each patient, the cumulative effective dose during a single hospital admission was calculated. Lifetime attributable risk (LAR) was estimated based on the BEIR VII, ICRP 103, and US EPA risk models to calculate additional oncogenic risk related to radiation exposure. The Friedman test for repeated-measures analysis of variance was used to compare risk values between different models. The intraclass correlation coefficient (ICC) was used to assess the consistency of risk values between different models. Results: Different organ, leukemia, and all-cancer risk values estimated according to different oncogenic risk models were significantly different, but the intraclass correlation coefficient revealed a good (>0.75) or even excellent (>0.9) agreement between different risk models. The ICRP 103 model estimated a lower all-cancer (median 69.05 [IQR 30.35–195.37]) and leukemia risk (8.22 [3.02–27.93]) compared to the US EPA (all-cancer: 139.68 [50.51–416.16]; leukemia: 23.34 [3.47–64.37]) and BEIR VII (all-cancer: 162.08 [70.6–371.40]; leukemia: 24.66 [12.9–58.8]) models. Conclusions: Cancer risk values were significantly different between risk models, though inter-model agreement in the consistency of risk values was found to be good, or even excellent.https://www.mdpi.com/2379-139X/11/4/42BEIR VIIoncogenic riskintensive care uniteffective dosecomputed tomographyradiation exposure |
| spellingShingle | Emilio Quaia Chiara Zanon Riccardo Torchio Fabrizio Dughiero Francesca De Monte Marta Paiusco Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients Tomography BEIR VII oncogenic risk intensive care unit effective dose computed tomography radiation exposure |
| title | Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients |
| title_full | Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients |
| title_fullStr | Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients |
| title_full_unstemmed | Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients |
| title_short | Variability Between Radiation-Induced Cancer Risk Models in Estimating Oncogenic Risk in Intensive Care Unit Patients |
| title_sort | variability between radiation induced cancer risk models in estimating oncogenic risk in intensive care unit patients |
| topic | BEIR VII oncogenic risk intensive care unit effective dose computed tomography radiation exposure |
| url | https://www.mdpi.com/2379-139X/11/4/42 |
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