Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction
Chlorantraniliprole, a widely used anthranilic diamide insecticide, has been linked to adverse effects on mammalian health, yet the precise toxicological mechanisms affecting intestine and brain remain unclear. In this study, mice were exposed to chlorantraniliprole at doses of 80, 160, and 320 mg/k...
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Elsevier
2025-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008103 |
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| author | Xin-Yu Wang Zi-Peng Li Bi-Yun Feng Jie Cheng Ji-Xiao Zhu Guang-Hui Xu Wei-Feng Huang Li-Tao Yi |
| author_facet | Xin-Yu Wang Zi-Peng Li Bi-Yun Feng Jie Cheng Ji-Xiao Zhu Guang-Hui Xu Wei-Feng Huang Li-Tao Yi |
| author_sort | Xin-Yu Wang |
| collection | DOAJ |
| description | Chlorantraniliprole, a widely used anthranilic diamide insecticide, has been linked to adverse effects on mammalian health, yet the precise toxicological mechanisms affecting intestine and brain remain unclear. In this study, mice were exposed to chlorantraniliprole at doses of 80, 160, and 320 mg/kg over a 28-day period. Significant damage to the intestinal barrier was observed, evidenced by decreased expression of tight junction protein ZO-1 and increased levels of inflammatory markers. Cognitive impairments, including decreased locomotor activity, impaired reward response, and increased anhedonia, were observed in behavioral tests. Oxidative stress was overactivated in both colonic and hippocampal tissues. Chlorantraniliprole exposure caused gut dysbiosis, characterized by an increase in Lactobacillus and Allobaculum and a reduction in Parabacteroides. In addition, short-chain fatty acid (SCFA) production decreased following chlorantraniliprole exposure. Metabolomic profiling revealed an increase in lipid-related metabolites and peptides, but a decrease in organic acids and nucleic acids, indicating metabolic dysregulation. Furthermore, iron accumulation and mitochondrial damage were observed in colonic tissue. These findings suggest that chronic chlorantraniliprole exposure disrupts intestinal and neural homeostasis through interconnected pathways involving inflammation, oxidative stress, gut microbiota alterations, and metabolic dysfunction. |
| format | Article |
| id | doaj-art-a95aa5ccd7de4a899f974acec4ed88f5 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-a95aa5ccd7de4a899f974acec4ed88f52025-08-20T03:45:28ZengElsevierEcotoxicology and Environmental Safety0147-65132025-07-0130011847010.1016/j.ecoenv.2025.118470Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunctionXin-Yu Wang0Zi-Peng Li1Bi-Yun Feng2Jie Cheng3Ji-Xiao Zhu4Guang-Hui Xu5Wei-Feng Huang6Li-Tao Yi7Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, PR ChinaDepartment of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, PR ChinaFujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, Fujian Province, PR ChinaDepartment of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, PR ChinaXiamen Medicine Research Institute, Xiamen 361008, Fujian Province, PR ChinaFujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, Fujian Province, PR ChinaResearch Center of Traditional Chinese Medicine Resources and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, PR China; Corresponding author.Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, PR China; Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, Fujian Province, PR China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; Corresponding author at: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, PR China.Chlorantraniliprole, a widely used anthranilic diamide insecticide, has been linked to adverse effects on mammalian health, yet the precise toxicological mechanisms affecting intestine and brain remain unclear. In this study, mice were exposed to chlorantraniliprole at doses of 80, 160, and 320 mg/kg over a 28-day period. Significant damage to the intestinal barrier was observed, evidenced by decreased expression of tight junction protein ZO-1 and increased levels of inflammatory markers. Cognitive impairments, including decreased locomotor activity, impaired reward response, and increased anhedonia, were observed in behavioral tests. Oxidative stress was overactivated in both colonic and hippocampal tissues. Chlorantraniliprole exposure caused gut dysbiosis, characterized by an increase in Lactobacillus and Allobaculum and a reduction in Parabacteroides. In addition, short-chain fatty acid (SCFA) production decreased following chlorantraniliprole exposure. Metabolomic profiling revealed an increase in lipid-related metabolites and peptides, but a decrease in organic acids and nucleic acids, indicating metabolic dysregulation. Furthermore, iron accumulation and mitochondrial damage were observed in colonic tissue. These findings suggest that chronic chlorantraniliprole exposure disrupts intestinal and neural homeostasis through interconnected pathways involving inflammation, oxidative stress, gut microbiota alterations, and metabolic dysfunction.http://www.sciencedirect.com/science/article/pii/S0147651325008103ChlorantraniliproleInflammationLipidAmino acidIntestinalCognition |
| spellingShingle | Xin-Yu Wang Zi-Peng Li Bi-Yun Feng Jie Cheng Ji-Xiao Zhu Guang-Hui Xu Wei-Feng Huang Li-Tao Yi Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction Ecotoxicology and Environmental Safety Chlorantraniliprole Inflammation Lipid Amino acid Intestinal Cognition |
| title | Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction |
| title_full | Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction |
| title_fullStr | Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction |
| title_full_unstemmed | Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction |
| title_short | Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction |
| title_sort | long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction |
| topic | Chlorantraniliprole Inflammation Lipid Amino acid Intestinal Cognition |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325008103 |
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