Protein C in adult patients with sepsis: from pathophysiology to monitoring and supplementation

Protein C in adult patients with sepsis: from pathophysiology to monitoring and supplementation

Abstract Protein C (PC) plays a crucial role in modulating inflammation and coagulation in sepsis. Its anticoagulant and cytoprotective properties are critical in mitigating sepsis-induced coagulopathy, which is associated with high mortality rates. In sepsis, low levels of PC are associated with an...

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Bibliographic Details
Main Authors: Irene Coloretti, Antonio Corcione, Gennaro De Pascale, Abele Donati, Francesco Forfori, Marco Marietta, Mauro Panigada, Paolo Simioni, Carlo Tascini, Pierluigi Viale, Massimo Girardis
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Anesthesia, Analgesia and Critical Care
Subjects:
Sepsis
Septic shock
Thrombosis
Disseminated intravascular coagulation
Activated protein C
Online Access:https://doi.org/10.1186/s44158-025-00243-0
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