Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Background. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases in urology, but its pathogenesis remains unclear. As a kind of chronic pain which the patients suffered for more than 3 months, we investigated the influence on patients’ brain functional connec...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6690414 |
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| author | Shengyang Ge Qingfeng Hu Yijun Guo Ke Xu Guowei Xia Chuanyu Sun |
| author_facet | Shengyang Ge Qingfeng Hu Yijun Guo Ke Xu Guowei Xia Chuanyu Sun |
| author_sort | Shengyang Ge |
| collection | DOAJ |
| description | Background. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases in urology, but its pathogenesis remains unclear. As a kind of chronic pain which the patients suffered for more than 3 months, we investigated the influence on patients’ brain functional connectivity in resting state. Methods. We recruited a cohort of 18 right-handed male patients with CP/CPPS and 21 healthy male right-handed age-matched controls. Their resting-state fMRI data and structural MRI data were preprocessed and processed by RESTPlus V1.22. To assess the integrity of the default mode network (DMN), we utilized the voxel-wised analysis that we set medial prefrontal cortex (mPFC) and posterior cingulate gyrus (PCC) as seed points to compare the global functional connectivity (FC) strength. Results. Compared with healthy control, the FC strength between left mPFC and posterior DMN decreased in the group of CP/CPPS (P<0.05, GFR correction, voxel P<0.01, cluster P<0.05), and the FC strength between the left anterior cerebellar lobe and posterior DMN increased (P<0.05, GFR correction, voxel P<0.01, cluster P<0.05). In the patient group, there was a positive correlation between the increased FC strength and the score of the Hospital Anxiety and Depression Scale (HADS) anxiety subscale (r=0.5509, P=0.0178) in the left anterior cerebellar lobe, a negative correlation between the decreased FC strength and the score of the National Institutes of Health Chronic Prostatitis Symptom Index (r=−0.6281, P=0.0053) in the area of left mPFC, and a negative correlation between the decreased FC strength and the score of HADS anxiety subscale (r=−0.5252, P=0.0252). Conclusion. Patients with CP/CPPS had alterations in brain function, which consisted of the default mode network’s compromised integrity. These alterations might play a crucial role in the pathogenesis and development of CP/CPPS. |
| format | Article |
| id | doaj-art-a94fc0b7938d42a1852a8e34c3c855c5 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-a94fc0b7938d42a1852a8e34c3c855c52025-08-20T02:20:33ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66904146690414Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain SyndromeShengyang Ge0Qingfeng Hu1Yijun Guo2Ke Xu3Guowei Xia4Chuanyu Sun5Department of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, ChinaDepartment of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, ChinaDepartment of Urology, Jing’an District Center Hospital of Shanghai, 259 Xikang Rd, Shanghai 200040, ChinaDepartment of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, ChinaDepartment of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, ChinaDepartment of Urology, Huashan Hospital, Fudan University, 12 Central Urumqi Rd, Shanghai 200040, ChinaBackground. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases in urology, but its pathogenesis remains unclear. As a kind of chronic pain which the patients suffered for more than 3 months, we investigated the influence on patients’ brain functional connectivity in resting state. Methods. We recruited a cohort of 18 right-handed male patients with CP/CPPS and 21 healthy male right-handed age-matched controls. Their resting-state fMRI data and structural MRI data were preprocessed and processed by RESTPlus V1.22. To assess the integrity of the default mode network (DMN), we utilized the voxel-wised analysis that we set medial prefrontal cortex (mPFC) and posterior cingulate gyrus (PCC) as seed points to compare the global functional connectivity (FC) strength. Results. Compared with healthy control, the FC strength between left mPFC and posterior DMN decreased in the group of CP/CPPS (P<0.05, GFR correction, voxel P<0.01, cluster P<0.05), and the FC strength between the left anterior cerebellar lobe and posterior DMN increased (P<0.05, GFR correction, voxel P<0.01, cluster P<0.05). In the patient group, there was a positive correlation between the increased FC strength and the score of the Hospital Anxiety and Depression Scale (HADS) anxiety subscale (r=0.5509, P=0.0178) in the left anterior cerebellar lobe, a negative correlation between the decreased FC strength and the score of the National Institutes of Health Chronic Prostatitis Symptom Index (r=−0.6281, P=0.0053) in the area of left mPFC, and a negative correlation between the decreased FC strength and the score of HADS anxiety subscale (r=−0.5252, P=0.0252). Conclusion. Patients with CP/CPPS had alterations in brain function, which consisted of the default mode network’s compromised integrity. These alterations might play a crucial role in the pathogenesis and development of CP/CPPS.http://dx.doi.org/10.1155/2021/6690414 |
| spellingShingle | Shengyang Ge Qingfeng Hu Yijun Guo Ke Xu Guowei Xia Chuanyu Sun Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome Neural Plasticity |
| title | Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_full | Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_fullStr | Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_full_unstemmed | Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_short | Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_sort | potential alterations of functional connectivity analysis in the patients with chronic prostatitis chronic pelvic pain syndrome |
| url | http://dx.doi.org/10.1155/2021/6690414 |
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