Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review
This report describes a rare case of a patient with lipoma presenting with epileptic seizures associated with expanding perifocal edema. The patient was a 48-year-old man who presented with loss of consciousness and convulsions. Magnetic resonance imaging (MRI) revealed a calcified mass in the corpu...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/520208 |
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| author | Michiyasu Fuga Toshihide Tanaka Yohei Yamamoto Yuzuru Hasegawa Yuichi Murayama Junko Takahashi-Fujigasaki |
| author_facet | Michiyasu Fuga Toshihide Tanaka Yohei Yamamoto Yuzuru Hasegawa Yuichi Murayama Junko Takahashi-Fujigasaki |
| author_sort | Michiyasu Fuga |
| collection | DOAJ |
| description | This report describes a rare case of a patient with lipoma presenting with epileptic seizures associated with expanding perifocal edema. The patient was a 48-year-old man who presented with loss of consciousness and convulsions. Magnetic resonance imaging (MRI) revealed a calcified mass in the corpus callosum with perifocal edema causing mass effect. An interhemispheric approach was used to biopsy the mass lesion. Histological examination revealed typical adipose cells, along with hamartomatous components. These components contained neurofilament and S-100-positive structures showing marked calcification. Fibrous cells immunoreactive for α-smooth muscle actin and epithelial membrane antigen proliferated with focal granulomatous inflammatory changes. MIB-1 index was approximately 5% in immature cells observed in granulomatous areas. We thus suspected a coexisting neoplastic component. The residual lesion persisted in a dormant state for 2 years following biopsy. Surgical resection of a lipoma is extremely difficult and potentially dangerous. However, in the present case, the lesion was accompanied by atypical, expanding, and perifocal edema. Surgical treatment was inevitable for the purpose of histological confirmation, considering differential diagnoses such as dermoid, epidermoid, and glioma. In the end, anticonvulsant therapy proved effective for controlling epileptic seizures. |
| format | Article |
| id | doaj-art-a94b39b1ec2f41d3af2831b4cbfc5607 |
| institution | OA Journals |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-a94b39b1ec2f41d3af2831b4cbfc56072025-08-20T02:20:33ZengWileyCase Reports in Neurological Medicine2090-66682090-66762015-01-01201510.1155/2015/520208520208Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature ReviewMichiyasu Fuga0Toshihide Tanaka1Yohei Yamamoto2Yuzuru Hasegawa3Yuichi Murayama4Junko Takahashi-Fujigasaki5Department of Neurosurgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, JapanDepartment of Neurosurgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, JapanDepartment of Neurosurgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, JapanDepartment of Neurosurgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, JapanDepartment of Neurosurgery, Jikei University School of Medicine, Tokyo, JapanDivision of Neuropathology, Jikei University School of Medicine, Tokyo, JapanThis report describes a rare case of a patient with lipoma presenting with epileptic seizures associated with expanding perifocal edema. The patient was a 48-year-old man who presented with loss of consciousness and convulsions. Magnetic resonance imaging (MRI) revealed a calcified mass in the corpus callosum with perifocal edema causing mass effect. An interhemispheric approach was used to biopsy the mass lesion. Histological examination revealed typical adipose cells, along with hamartomatous components. These components contained neurofilament and S-100-positive structures showing marked calcification. Fibrous cells immunoreactive for α-smooth muscle actin and epithelial membrane antigen proliferated with focal granulomatous inflammatory changes. MIB-1 index was approximately 5% in immature cells observed in granulomatous areas. We thus suspected a coexisting neoplastic component. The residual lesion persisted in a dormant state for 2 years following biopsy. Surgical resection of a lipoma is extremely difficult and potentially dangerous. However, in the present case, the lesion was accompanied by atypical, expanding, and perifocal edema. Surgical treatment was inevitable for the purpose of histological confirmation, considering differential diagnoses such as dermoid, epidermoid, and glioma. In the end, anticonvulsant therapy proved effective for controlling epileptic seizures.http://dx.doi.org/10.1155/2015/520208 |
| spellingShingle | Michiyasu Fuga Toshihide Tanaka Yohei Yamamoto Yuzuru Hasegawa Yuichi Murayama Junko Takahashi-Fujigasaki Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review Case Reports in Neurological Medicine |
| title | Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review |
| title_full | Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review |
| title_fullStr | Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review |
| title_full_unstemmed | Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review |
| title_short | Lipoma in the Corpus Callosum Presenting with Epileptic Seizures Associated with Expanding Perifocal Edema: A Case Report and Literature Review |
| title_sort | lipoma in the corpus callosum presenting with epileptic seizures associated with expanding perifocal edema a case report and literature review |
| url | http://dx.doi.org/10.1155/2015/520208 |
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