Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Abstract In patients with congenital heart disease, the development of pulmonary arterial hypertension (PAH) is based on vascular exposure to abnormal hemodynamic forces. In our work using a large animal model of increased pulmonary blood flow and pressure, we have previously described a pattern of...

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Bibliographic Details
Main Authors: Jason T. Boehme, Sanjeev A. Datar, Xutong Sun, Wenhui Gong, Qing Lu, Jamie Soto, Michael A. Smith, Alejandro E. Garcia-Flores, Gary W. Raff, Ting Wang, Emin Maltepe, Stephen M. Black, Jeffrey R. Fineman
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
HIF-1α
Mitochondrial ROS
Mechanotransduction
Nitric oxide
Pulmonary hypertension
Congenital heart disease
Online Access:https://doi.org/10.1038/s41598-025-99062-0
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