Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1
Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA defic...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2020/6313176 |
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| author | Paula F. Aarestrup Matheus F. Aarestrup Beatriz J. V. Aarestrup Fernando M. Aarestrup |
| author_facet | Paula F. Aarestrup Matheus F. Aarestrup Beatriz J. V. Aarestrup Fernando M. Aarestrup |
| author_sort | Paula F. Aarestrup |
| collection | DOAJ |
| description | Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency. |
| format | Article |
| id | doaj-art-a94385a8d498498fbcc3beac2801a6e6 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-a94385a8d498498fbcc3beac2801a6e62025-08-20T03:39:37ZengWileyCase Reports in Otolaryngology2090-67652090-67732020-01-01202010.1155/2020/63131766313176Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1Paula F. Aarestrup0Matheus F. Aarestrup1Beatriz J. V. Aarestrup2Fernando M. Aarestrup3Universidade Federal do Rio de Janeiro–UNIRIO, Rio de Janeiro, BrazilInstituto de Ensino Superior Tancredo Neves–IPTAN, São João Del Rei, Minas Gerais, BrazilLaboratory of Immunopathology and Experimental Pathology (CBR), Department of Morphology (ICB), Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilChairman Laboratory of Immunopathology and Experimental Pathology (CBR), Universidade Federal de Juiz de Fora, Chief Allergy and Immunology Service, Faculdade de Ciências Médicas e da Saúde – SUPREMA e Hospital Maternidade Therezinha de Jesus, Juiz de Fora, Minas Gerais, BrazilSelective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency.http://dx.doi.org/10.1155/2020/6313176 |
| spellingShingle | Paula F. Aarestrup Matheus F. Aarestrup Beatriz J. V. Aarestrup Fernando M. Aarestrup Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1 Case Reports in Otolaryngology |
| title | Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1 |
| title_full | Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1 |
| title_fullStr | Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1 |
| title_full_unstemmed | Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1 |
| title_short | Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1 |
| title_sort | prophylaxis of upper airway infections in a patient with partial iga deficiency concurrent use of sublingual immunotherapy with inactivated whole cell bacterial extract and der p1 |
| url | http://dx.doi.org/10.1155/2020/6313176 |
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