Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction
Objective. Aldosterone receptor blockade regulate activity of matrix metalloproteinase system, increase survival in postinfarction period. Methods and results. In order to study the influence of aldosterone receptor blockade on the serum level of collagen of I and III types, condition of MMP/TIMP...
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| Format: | Article |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-08-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/50259/47684 |
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| author | S. M. Kyselov |
| author_facet | S. M. Kyselov |
| author_sort | S. M. Kyselov |
| collection | DOAJ |
| description | Objective. Aldosterone receptor blockade regulate activity of matrix metalloproteinase system, increase survival in postinfarction period.
Methods and results. In order to study the influence of aldosterone receptor blockade on the serum level of collagen of I and III types, condition of MMP/TIMP system, early postinfarction remodeling of the left ventricle after Q-wave myocardial infarction was studied in 89 patients. The next methods were used: immunoassay analysis of the serum levels of matrix metalloproteinase and its inhibitor, echocardiography. Also systolic and diastolic heart functions were assessed.
Conclusion. Under the influence of the treatment it was showed that the intensity of the degradation of connective tissue matrix of the myocardium reduced, and was accompanied by improvement of the left ventricular systolic and diastolic function. |
| format | Article |
| id | doaj-art-a933b915af0643328da9b991372c19f3 |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-a933b915af0643328da9b991372c19f32025-08-20T03:18:50ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-08-0142630http://dx.doi.org/10.14739/2310-1210.2015.4.50259Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarctionS. M. KyselovObjective. Aldosterone receptor blockade regulate activity of matrix metalloproteinase system, increase survival in postinfarction period. Methods and results. In order to study the influence of aldosterone receptor blockade on the serum level of collagen of I and III types, condition of MMP/TIMP system, early postinfarction remodeling of the left ventricle after Q-wave myocardial infarction was studied in 89 patients. The next methods were used: immunoassay analysis of the serum levels of matrix metalloproteinase and its inhibitor, echocardiography. Also systolic and diastolic heart functions were assessed. Conclusion. Under the influence of the treatment it was showed that the intensity of the degradation of connective tissue matrix of the myocardium reduced, and was accompanied by improvement of the left ventricular systolic and diastolic function.http://zmj.zsmu.edu.ua/article/view/50259/47684CollagenMatrix Metalloproteinase-9Tissue Inhibitor Of Metalloproteinase-1 |
| spellingShingle | S. M. Kyselov Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction Zaporožskij Medicinskij Žurnal Collagen Matrix Metalloproteinase-9 Tissue Inhibitor Of Metalloproteinase-1 |
| title | Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction |
| title_full | Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction |
| title_fullStr | Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction |
| title_full_unstemmed | Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction |
| title_short | Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction |
| title_sort | influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with q wave myocardial infarction |
| topic | Collagen Matrix Metalloproteinase-9 Tissue Inhibitor Of Metalloproteinase-1 |
| url | http://zmj.zsmu.edu.ua/article/view/50259/47684 |
| work_keys_str_mv | AT smkyselov influenceofdiureticswithantialdosteroneeffectontheconditionofextracellularmatrixandearlypostinfarctionremodelingoftheleftventricleinpatientswithqwavemyocardialinfarction |