Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature
<b>Background:</b> Lemierre syndrome is a rare and life-threatening disease. It is characterized by septic thrombophlebitis of the internal jugular vein, historically associated with <i>Fusobacterium necrophorum</i> infection. However, atypical cases and associations with oth...
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2024-11-01
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| author | Luca Pipitò Antonio Anastasia Fabrizio Passalacqua Giulio D’Agati Floriana Di Figlia Benedetta Romanin Silvia Bonura Raffaella Rubino Agostino Inzerillo Caterina Sarno Antonio Cascio |
| author_facet | Luca Pipitò Antonio Anastasia Fabrizio Passalacqua Giulio D’Agati Floriana Di Figlia Benedetta Romanin Silvia Bonura Raffaella Rubino Agostino Inzerillo Caterina Sarno Antonio Cascio |
| author_sort | Luca Pipitò |
| collection | DOAJ |
| description | <b>Background:</b> Lemierre syndrome is a rare and life-threatening disease. It is characterized by septic thrombophlebitis of the internal jugular vein, historically associated with <i>Fusobacterium necrophorum</i> infection. However, atypical cases and associations with other organisms have been reported. <b>Methods:</b> Here, we describe a challenging case of Lemierre syndrome in a 71-year-old woman caused by <i>Streptococcus constellatus</i> and review the related literature. <b>Case:</b> The patient experienced multiple hospital admissions due to misdiagnoses and developed thrombosis involving the internal jugular vein and transverse sinus bilaterally, pulmonary complications including the formation of a pseudoaneurysm, and occipital abscess. She presented with headaches, neck pain, and blindness. Prolonged antibiotic therapy was administered, leading to gradual improvement of symptoms, with partial resolution of blindness. Prophylaxis with intramuscular penicillin was prescribed at discharge. <b>Conclusions:</b> Our case underscores the importance of considering Lemierre syndrome in patients who present with multiple thrombotic events affecting the intracranial circulation and/or jugular veins, particularly in those already receiving anticoagulation therapy or with no identifiable cause for thrombosis, even in the absence of sore throat or fever. |
| format | Article |
| id | doaj-art-a933b441e2774735a4b62da4e77a407a |
| institution | DOAJ |
| issn | 2036-7449 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj-art-a933b441e2774735a4b62da4e77a407a2025-08-20T02:53:33ZengMDPI AGInfectious Disease Reports2036-74492024-11-011661064107410.3390/idr16060086Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the LiteratureLuca Pipitò0Antonio Anastasia1Fabrizio Passalacqua2Giulio D’Agati3Floriana Di Figlia4Benedetta Romanin5Silvia Bonura6Raffaella Rubino7Agostino Inzerillo8Caterina Sarno9Antonio Cascio10Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G D’Alessandro”, University of Palermo, 90133 Palermo, ItalyInfectious and Tropical Disease Unit, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyDepartment of Radiological Sciences, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G D’Alessandro”, University of Palermo, 90133 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G D’Alessandro”, University of Palermo, 90133 Palermo, ItalyInfectious and Tropical Disease Unit, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyInfectious and Tropical Disease Unit, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyInfectious and Tropical Disease Unit, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyDepartment of Radiological Sciences, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyDepartment of Radiological Sciences, AOU Policlinico “P. Giaccone”, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G D’Alessandro”, University of Palermo, 90133 Palermo, Italy<b>Background:</b> Lemierre syndrome is a rare and life-threatening disease. It is characterized by septic thrombophlebitis of the internal jugular vein, historically associated with <i>Fusobacterium necrophorum</i> infection. However, atypical cases and associations with other organisms have been reported. <b>Methods:</b> Here, we describe a challenging case of Lemierre syndrome in a 71-year-old woman caused by <i>Streptococcus constellatus</i> and review the related literature. <b>Case:</b> The patient experienced multiple hospital admissions due to misdiagnoses and developed thrombosis involving the internal jugular vein and transverse sinus bilaterally, pulmonary complications including the formation of a pseudoaneurysm, and occipital abscess. She presented with headaches, neck pain, and blindness. Prolonged antibiotic therapy was administered, leading to gradual improvement of symptoms, with partial resolution of blindness. Prophylaxis with intramuscular penicillin was prescribed at discharge. <b>Conclusions:</b> Our case underscores the importance of considering Lemierre syndrome in patients who present with multiple thrombotic events affecting the intracranial circulation and/or jugular veins, particularly in those already receiving anticoagulation therapy or with no identifiable cause for thrombosis, even in the absence of sore throat or fever.https://www.mdpi.com/2036-7449/16/6/86<i>Streptococcus constellatus</i>Lemierre syndromethrombosesinternal jugular thrombosistransverse sinus thrombosis |
| spellingShingle | Luca Pipitò Antonio Anastasia Fabrizio Passalacqua Giulio D’Agati Floriana Di Figlia Benedetta Romanin Silvia Bonura Raffaella Rubino Agostino Inzerillo Caterina Sarno Antonio Cascio Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature Infectious Disease Reports <i>Streptococcus constellatus</i> Lemierre syndrome thromboses internal jugular thrombosis transverse sinus thrombosis |
| title | Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature |
| title_full | Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature |
| title_fullStr | Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature |
| title_full_unstemmed | Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature |
| title_short | Lemierre Syndrome Associated with <i>Streptococcus constellatus</i> and Atypical Vascular Involvement: A Case Report and Review of the Literature |
| title_sort | lemierre syndrome associated with i streptococcus constellatus i and atypical vascular involvement a case report and review of the literature |
| topic | <i>Streptococcus constellatus</i> Lemierre syndrome thromboses internal jugular thrombosis transverse sinus thrombosis |
| url | https://www.mdpi.com/2036-7449/16/6/86 |
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