Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury

Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury

Abstract Genotoxic therapy triggers reactive oxygen species (ROS) production and oxidative tissue injury. S-nitrosylation is a selective and reversible posttranslational modification of protein thiols by nitric oxide (NO), and 5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for NO synthes...

Full description

Saved in:
Bibliographic Details
Main Authors: Yang Feng, Yahui Feng, Liming Gu, Wei Mo, Xi Wang, Bin Song, Min Hong, Fenghao Geng, Pei Huang, Hongying Yang, Wei Zhu, Yang Jiao, Qi Zhang, Wei-Qun Ding, Jianping Cao, Shuyu Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2024-05-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01208-z
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items