FHIT Doubts are Clear Now
The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter reg...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.110 |
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| _version_ | 1832563110265749504 |
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| author | Anjilna Wali |
| author_facet | Anjilna Wali |
| author_sort | Anjilna Wali |
| collection | DOAJ |
| description | The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter region showed that it is one of the important and preliminary genetic alterations in the cell, and its restoration in the cell line or nude mice suppresses tumorigenicity. Current research on the FHIT gene has depicted that Fhit interacts with different proteins through different pathways in the nucleus, mitochondria, and cytoplasm, directing the cell to apoptosis. |
| format | Article |
| id | doaj-art-a927d983530f4a198511e326a2966cc8 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a927d983530f4a198511e326a2966cc82025-02-03T01:20:56ZengWileyThe Scientific World Journal1537-744X2010-01-01101142115110.1100/tsw.2010.110FHIT Doubts are Clear NowAnjilna Wali0Cell and Molecular Biology Laboratory, Department of Biotechnology, University of Pune, Pune, Maharashtra, IndiaThe fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter region showed that it is one of the important and preliminary genetic alterations in the cell, and its restoration in the cell line or nude mice suppresses tumorigenicity. Current research on the FHIT gene has depicted that Fhit interacts with different proteins through different pathways in the nucleus, mitochondria, and cytoplasm, directing the cell to apoptosis.http://dx.doi.org/10.1100/tsw.2010.110 |
| spellingShingle | Anjilna Wali FHIT Doubts are Clear Now The Scientific World Journal |
| title | FHIT Doubts are Clear Now |
| title_full | FHIT Doubts are Clear Now |
| title_fullStr | FHIT Doubts are Clear Now |
| title_full_unstemmed | FHIT Doubts are Clear Now |
| title_short | FHIT Doubts are Clear Now |
| title_sort | fhit doubts are clear now |
| url | http://dx.doi.org/10.1100/tsw.2010.110 |
| work_keys_str_mv | AT anjilnawali fhitdoubtsareclearnow |