A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives
Background/objectiveHypervirulent Klebsiella pneumoniae (hvKP) is an emerging global health threat, exhibiting increased virulence and multidrug resistance compared to classic K. pneumoniae. Understanding the research landscape surrounding hvKP is crucial for developing effective control strategies....
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1545678/full |
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| author | Tian Tian Hui Han Zhi-Hui Guan Ke Zhang Xinghe Huang Wenyue Wang Xuan Zhang Fei Zhang Leijia Wei Xin Zhang Jia-He Wang |
| author_facet | Tian Tian Hui Han Zhi-Hui Guan Ke Zhang Xinghe Huang Wenyue Wang Xuan Zhang Fei Zhang Leijia Wei Xin Zhang Jia-He Wang |
| author_sort | Tian Tian |
| collection | DOAJ |
| description | Background/objectiveHypervirulent Klebsiella pneumoniae (hvKP) is an emerging global health threat, exhibiting increased virulence and multidrug resistance compared to classic K. pneumoniae. Understanding the research landscape surrounding hvKP is crucial for developing effective control strategies. This study aimed to comprehensively analyze the global research trends in hvKP from 2013 to 2024 using bibliometric and topic modeling techniques.MethodsData from 1,014 articles on hvKP, retrieved from the Web of Science Core Collection, were analyzed using Bibliometrix, CiteSpace, and VOSviewer to assess publication trends, collaborations, geographical distribution, and keyword co-occurrence. Latent Dirichlet Allocation (LDA) topic modeling was employed to identify key research themes.ResultsThe analysis revealed a steadily increasing volume of hvKP research, with China and the United States as major contributors. Four primary research themes emerged: high virulence phenotypes and mechanisms; drug resistance and treatment strategies; genetic and molecular mechanisms; and epidemiological and transmission characteristics. Research hotspots included virulence mechanisms, drug resistance, genomic detection approaches, and epidemiological features.ConclusionThis bibliometric analysis provides a comprehensive overview of hvKP research, highlighting key trends and research gaps. The identified research hotspots inform future research directions and contribute to the development of effective strategies for combating hvKP infections. The increasing research volume underscores the urgent need for continued investigation into this significant public health threat. |
| format | Article |
| id | doaj-art-a9256703f9ab40e4bda7e70397e07ea4 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-a9256703f9ab40e4bda7e70397e07ea42025-08-20T02:16:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15456781545678A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectivesTian Tian0Hui Han1Zhi-Hui Guan2Ke Zhang3Xinghe Huang4Wenyue Wang5Xuan Zhang6Fei Zhang7Leijia Wei8Xin Zhang9Jia-He Wang10Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaScience and Technology Research Center of China Customs, Beijing, ChinaDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, ChinaDepartment of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, ChinaCollege of Metrology and Measurement Engineering, China Jiliang University, Hangzhou, ChinaDepartment of General Practice, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Infection Diseases, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, ChinaBackground/objectiveHypervirulent Klebsiella pneumoniae (hvKP) is an emerging global health threat, exhibiting increased virulence and multidrug resistance compared to classic K. pneumoniae. Understanding the research landscape surrounding hvKP is crucial for developing effective control strategies. This study aimed to comprehensively analyze the global research trends in hvKP from 2013 to 2024 using bibliometric and topic modeling techniques.MethodsData from 1,014 articles on hvKP, retrieved from the Web of Science Core Collection, were analyzed using Bibliometrix, CiteSpace, and VOSviewer to assess publication trends, collaborations, geographical distribution, and keyword co-occurrence. Latent Dirichlet Allocation (LDA) topic modeling was employed to identify key research themes.ResultsThe analysis revealed a steadily increasing volume of hvKP research, with China and the United States as major contributors. Four primary research themes emerged: high virulence phenotypes and mechanisms; drug resistance and treatment strategies; genetic and molecular mechanisms; and epidemiological and transmission characteristics. Research hotspots included virulence mechanisms, drug resistance, genomic detection approaches, and epidemiological features.ConclusionThis bibliometric analysis provides a comprehensive overview of hvKP research, highlighting key trends and research gaps. The identified research hotspots inform future research directions and contribute to the development of effective strategies for combating hvKP infections. The increasing research volume underscores the urgent need for continued investigation into this significant public health threat.https://www.frontiersin.org/articles/10.3389/fmed.2025.1545678/fullhypervirulent Klebsiella pneumoniaeKlebsiella pneumoniaehypervirulenceantimicrobial resistancebibliometricstopic modeling |
| spellingShingle | Tian Tian Hui Han Zhi-Hui Guan Ke Zhang Xinghe Huang Wenyue Wang Xuan Zhang Fei Zhang Leijia Wei Xin Zhang Jia-He Wang A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives Frontiers in Medicine hypervirulent Klebsiella pneumoniae Klebsiella pneumoniae hypervirulence antimicrobial resistance bibliometrics topic modeling |
| title | A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives |
| title_full | A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives |
| title_fullStr | A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives |
| title_full_unstemmed | A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives |
| title_short | A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives |
| title_sort | systematic review of hypervirulent klebsiella pneumoniae research bibliometric and topic modeling perspectives |
| topic | hypervirulent Klebsiella pneumoniae Klebsiella pneumoniae hypervirulence antimicrobial resistance bibliometrics topic modeling |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1545678/full |
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