Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.
Acupuncture is reported to be effective in treating obesity related illnesses, but its mechanism is still unclear. To investigate this mechanism we applied electro-acupuncture (EA) in a mouse model of obesity and used RNA-seq to identify molecular consequences. Deletion of the transcription factor S...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181948&type=printable |
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| author | Shu-Ping Fu Hao Hong Sheng-Feng Lu Chen-Jun Hu Hou-Xi Xu Qian Li Mei-Ling Yu Chen Ou Jian-Zhong Meng Tian-Lin Wang Lothar Hennighausen Bing-Mei Zhu |
| author_facet | Shu-Ping Fu Hao Hong Sheng-Feng Lu Chen-Jun Hu Hou-Xi Xu Qian Li Mei-Ling Yu Chen Ou Jian-Zhong Meng Tian-Lin Wang Lothar Hennighausen Bing-Mei Zhu |
| author_sort | Shu-Ping Fu |
| collection | DOAJ |
| description | Acupuncture is reported to be effective in treating obesity related illnesses, but its mechanism is still unclear. To investigate this mechanism we applied electro-acupuncture (EA) in a mouse model of obesity and used RNA-seq to identify molecular consequences. Deletion of the transcription factor STAT5 from neurons (Stat5NKO) led to obesity. Acupuncture, in turn, reduced body weight and the ratio of epididymal white adipose tissue (Epi-WAT) to body weight, and it also decreased plasma concentrations of glucose, triglyceride, and cholesterol. In addition, EA increased cold endurance of Stat5NKO obese mice. EA reversed altered gene expressions in the hypothalamus and Epi-WAT, especially in the hypothalamus in Stat5NKO obese mice. This study provides, for the first time, insight into genomic networks of obesity and their modulation by electro-acupuncture, which in turn reveals potential mechanisms that explain acupuncture-induced weight-loss. |
| format | Article |
| id | doaj-art-a91b8fe9fb564e10befec63b7f5c64fc |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a91b8fe9fb564e10befec63b7f5c64fc2025-08-20T02:45:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018194810.1371/journal.pone.0181948Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.Shu-Ping FuHao HongSheng-Feng LuChen-Jun HuHou-Xi XuQian LiMei-Ling YuChen OuJian-Zhong MengTian-Lin WangLothar HennighausenBing-Mei ZhuAcupuncture is reported to be effective in treating obesity related illnesses, but its mechanism is still unclear. To investigate this mechanism we applied electro-acupuncture (EA) in a mouse model of obesity and used RNA-seq to identify molecular consequences. Deletion of the transcription factor STAT5 from neurons (Stat5NKO) led to obesity. Acupuncture, in turn, reduced body weight and the ratio of epididymal white adipose tissue (Epi-WAT) to body weight, and it also decreased plasma concentrations of glucose, triglyceride, and cholesterol. In addition, EA increased cold endurance of Stat5NKO obese mice. EA reversed altered gene expressions in the hypothalamus and Epi-WAT, especially in the hypothalamus in Stat5NKO obese mice. This study provides, for the first time, insight into genomic networks of obesity and their modulation by electro-acupuncture, which in turn reveals potential mechanisms that explain acupuncture-induced weight-loss.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181948&type=printable |
| spellingShingle | Shu-Ping Fu Hao Hong Sheng-Feng Lu Chen-Jun Hu Hou-Xi Xu Qian Li Mei-Ling Yu Chen Ou Jian-Zhong Meng Tian-Lin Wang Lothar Hennighausen Bing-Mei Zhu Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. PLoS ONE |
| title | Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. |
| title_full | Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. |
| title_fullStr | Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. |
| title_full_unstemmed | Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. |
| title_short | Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice. |
| title_sort | genome wide regulation of electro acupuncture on the neural stat5 loss induced obese mice |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181948&type=printable |
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