Acute toxicity outcomes in Egyptian early-stage breast cancer: ultra-hypofractionated versus hypofractionated radiotherapy
Abstract Background Comparison of acute adverse events (acute skin reaction, acute breast pain and lung toxicities) in early-stage breast cancer using 2 different fractionation schedules: ultra-hypofractionation versus hypofractionation radiotherapy. Methods Ninety-two patients were recruited and as...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-05-01
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| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43046-025-00280-4 |
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| Summary: | Abstract Background Comparison of acute adverse events (acute skin reaction, acute breast pain and lung toxicities) in early-stage breast cancer using 2 different fractionation schedules: ultra-hypofractionation versus hypofractionation radiotherapy. Methods Ninety-two patients were recruited and assessed using RTOG criteria for acute skin reactions at the end of radiotherapy, 1 month after, and 3 months after. Results There have been no statistically significant differences in acute skin adverse events in 1 month after WBI, there have been neither G3 acute skin toxicity nor G2 skin reactions as were in the fast trial, and milder than skin adverse events in the FAST-FORWARD trial. Acute breast pain at the end of radiotherapy has been statistically significantly lower in arm 1 vs arm 2. Acute breast pain at 1-month follow-up has been comparable between the study arms, with no statistically significant difference. At the 3-month follow-up, acute breast pain was similar in both arms. In all arms, no acute lung toxicities have been reported. Conclusion Acute adverse events have been comparable between ultra-hypofractionation and hypofractionation. |
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| ISSN: | 2589-0409 |