Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis.

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis.

<h4>Background</h4>It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test the hypothesis that common genetic variants can predict response to an...

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Main Authors: Katherine E Tansey, Michel Guipponi, Nader Perroud, Guido Bondolfi, Enrico Domenici, David Evans, Stephanie K Hall, Joanna Hauser, Neven Henigsberg, Xiaolan Hu, Borut Jerman, Wolfgang Maier, Ole Mors, Michael O'Donovan, Tim J Peters, Anna Placentino, Marcella Rietschel, Daniel Souery, Katherine J Aitchison, Ian Craig, Anne Farmer, Jens R Wendland, Alain Malafosse, Peter Holmans, Glyn Lewis, Cathryn M Lewis, Tine Bryan Stensbøl, Shitij Kapur, Peter McGuffin, Rudolf Uher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1001326
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