Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are FDA-approved for weight loss and are increasingly prescribed for patients with obesity and type 2 diabetes mellitus. Multiple studies have demonstrated desirable renal and cardiovascular benefits from these novel agent...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2025-01-01
|
| Series: | Glomerular Diseases |
| Online Access: | https://karger.com/article/doi/10.1159/000543357 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849321623603118080 |
|---|---|
| author | Karthik Kovvuru Swetha Rani Kanduri Johnathon Phillips Juan Carlos Velez |
| author_facet | Karthik Kovvuru Swetha Rani Kanduri Johnathon Phillips Juan Carlos Velez |
| author_sort | Karthik Kovvuru |
| collection | DOAJ |
| description |
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are FDA-approved for weight loss and are increasingly prescribed for patients with obesity and type 2 diabetes mellitus. Multiple studies have demonstrated desirable renal and cardiovascular benefits from these novel agents. So far, a few case reports of acute tubular injury and acute interstitial nephritis have been reported with GLP-1RA. Podocytopathies in association with semaglutide are rare. In this case report, we present a case of nephrotic syndrome that developed after exposure to semaglutide and propose potential pathophysiological mechanisms underlying this rare renal complication. Case Presentation: Herein, we report a novel case of a 43-year-old female who was evaluated in the nephrology clinic for abrupt onset of bilateral lower extremity edema and foamy urine, a few weeks after exposure to semaglutide. She was diagnosed with nephrotic syndrome and subsequently underwent a kidney biopsy, which revealed features suggestive of minimal change disease, along with coexistent thin basement membrane disease. Conclusion: GLP-1RAs have been increasingly prescribed due to their proven pleiotropic benefits, including improvements in albuminuria, glycemic control, weight loss, and cardioprotective effects. Despite the considerable benefits of GLP-1RAs, it is essential to recognize novel side effects. |
| format | Article |
| id | doaj-art-a90be6326e9c41c8a0e2a466171aa3ae |
| institution | Kabale University |
| issn | 2673-3633 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Glomerular Diseases |
| spelling | doaj-art-a90be6326e9c41c8a0e2a466171aa3ae2025-08-20T03:49:41ZengKarger PublishersGlomerular Diseases2673-36332025-01-015110310810.1159/000543357Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to SemaglutideKarthik KovvuruSwetha Rani KanduriJohnathon PhillipsJuan Carlos Velez Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are FDA-approved for weight loss and are increasingly prescribed for patients with obesity and type 2 diabetes mellitus. Multiple studies have demonstrated desirable renal and cardiovascular benefits from these novel agents. So far, a few case reports of acute tubular injury and acute interstitial nephritis have been reported with GLP-1RA. Podocytopathies in association with semaglutide are rare. In this case report, we present a case of nephrotic syndrome that developed after exposure to semaglutide and propose potential pathophysiological mechanisms underlying this rare renal complication. Case Presentation: Herein, we report a novel case of a 43-year-old female who was evaluated in the nephrology clinic for abrupt onset of bilateral lower extremity edema and foamy urine, a few weeks after exposure to semaglutide. She was diagnosed with nephrotic syndrome and subsequently underwent a kidney biopsy, which revealed features suggestive of minimal change disease, along with coexistent thin basement membrane disease. Conclusion: GLP-1RAs have been increasingly prescribed due to their proven pleiotropic benefits, including improvements in albuminuria, glycemic control, weight loss, and cardioprotective effects. Despite the considerable benefits of GLP-1RAs, it is essential to recognize novel side effects. https://karger.com/article/doi/10.1159/000543357 |
| spellingShingle | Karthik Kovvuru Swetha Rani Kanduri Johnathon Phillips Juan Carlos Velez Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide Glomerular Diseases |
| title | Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide |
| title_full | Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide |
| title_fullStr | Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide |
| title_full_unstemmed | Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide |
| title_short | Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide |
| title_sort | minimal change podocytopathy with coexistent thin glomerular basement membrane following exposure to semaglutide |
| url | https://karger.com/article/doi/10.1159/000543357 |
| work_keys_str_mv | AT karthikkovvuru minimalchangepodocytopathywithcoexistentthinglomerularbasementmembranefollowingexposuretosemaglutide AT swetharanikanduri minimalchangepodocytopathywithcoexistentthinglomerularbasementmembranefollowingexposuretosemaglutide AT johnathonphillips minimalchangepodocytopathywithcoexistentthinglomerularbasementmembranefollowingexposuretosemaglutide AT juancarlosvelez minimalchangepodocytopathywithcoexistentthinglomerularbasementmembranefollowingexposuretosemaglutide |