Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study

Rasheed Ibdah,1,* Mohammed Al-Nusair,1,* Raghad Abuhalimeh,2 Saad A Mahmoud,1 Bushra Laswi,1 Sukaina Rawashdeh,1 Ayman Hamoudeh,3 Khalid A Kheirallah4 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jo...

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Main Authors: Ibdah R, Al-Nusair M, Abuhalimeh R, Mahmoud SA, Laswi B, Rawashdeh S, Hamoudeh A, Kheirallah KA
Format: Article
Language:English
Published: Dove Medical Press 2025-01-01
Series:International Journal of Women's Health
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Online Access:https://www.dovepress.com/traditional-and-non-traditional-risk-factors-of-acute-coronary-syndrom-peer-reviewed-fulltext-article-IJWH
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author Ibdah R
Al-Nusair M
Abuhalimeh R
Mahmoud SA
Laswi B
Rawashdeh S
Hamoudeh A
Kheirallah KA
author_facet Ibdah R
Al-Nusair M
Abuhalimeh R
Mahmoud SA
Laswi B
Rawashdeh S
Hamoudeh A
Kheirallah KA
author_sort Ibdah R
collection DOAJ
description Rasheed Ibdah,1,&ast; Mohammed Al-Nusair,1,&ast; Raghad Abuhalimeh,2 Saad A Mahmoud,1 Bushra Laswi,1 Sukaina Rawashdeh,1 Ayman Hamoudeh,3 Khalid A Kheirallah4 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2School of Medicine, University of Jordan, Amman, Jordan; 3Department of Cardiology, Istishari Hospital, Amman, Jordan; 4Department of Public Health and Community Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan&ast;These authors contributed equally to this workCorrespondence: Khalid A Kheirallah, Jordan University of Science and Technology, P. O.Box 3030, Irbid, 22110, Jordan, Email kkheiral@gmail.comPurpose: Young women are at risk of acute coronary syndrome (ACS). They represent a unique population exposed to traditional cardiovascular risk factors and female sex-specific, non-traditional risk factors. The current study aimed to describe traditional and non-traditional risk factors of ACS in young women from the Middle East.Patients and Methods: The present study used data from the Jordanian, nationwide, multicenter, case-control study, ANCORS-YW. Bivariate analyses and logistic regression models were used to predict independent risk factors of ACS using adjusted odds ratios (AOR) and 95% confidence intervals (CI).Results: The study included 572 young women (≤ 50-years) with a median age of 45-years, divided into an ACS group (n=154, 26.9%) and a control group with no atherosclerotic cardiovascular disease (n=418, 73.1%). The most common presentation of ACS was non-ST-elevation ACS (n=98, 64%). The ACS group, compared to control group, had higher proportions of type-2 diabetes (41.6%vs.11.7%, p< 0.001), hypertension (53.9%vs.23.4%, p< 0.001), tobacco use (37.7%vs.24.2%, p=0.001), family history of cardiovascular disease (53.2%vs.23.4%, p< 0.001), metabolic syndrome (14.3%vs.2.4%, p< 0.001), and preterm delivery (24.7%vs.16.7%, p=0.032). ACS group had nonsignificantly greater proportions of hypertensive disorders of pregnancy (29.2%vs.22.7%, p=0.109) and gestational diabetes (15.6%vs.10.3%, p=0.081). Multivariable logistic regression analyses identified five independent predictors of ACS: type-2 diabetes (AOR, 95% CI: 3.45, 1.98&boxh;5.99), family history of cardiovascular disease (3.33, 2.15&boxh;5.17), tobacco use (2.01, 1.26&boxh;3.21), hypertension (1.72, 1.07&boxh;2.78), and metabolic syndrome (4.35, 1.72&boxh;11.03).Conclusion: Modifiable risk factors play an important role in ACS risk among young women. Efforts should be made to improve primordial and primary prevention in this population.Keywords: cardiovascular, female, ischemic heart disease, prevention, myocardial infarction
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spelling doaj-art-a908d75071d546678b455692f7e07e362025-01-23T18:50:32ZengDove Medical PressInternational Journal of Women's Health1179-14112025-01-01Volume 1713915299543Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW StudyIbdah RAl-Nusair MAbuhalimeh RMahmoud SALaswi BRawashdeh SHamoudeh AKheirallah KARasheed Ibdah,1,&ast; Mohammed Al-Nusair,1,&ast; Raghad Abuhalimeh,2 Saad A Mahmoud,1 Bushra Laswi,1 Sukaina Rawashdeh,1 Ayman Hamoudeh,3 Khalid A Kheirallah4 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2School of Medicine, University of Jordan, Amman, Jordan; 3Department of Cardiology, Istishari Hospital, Amman, Jordan; 4Department of Public Health and Community Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan&ast;These authors contributed equally to this workCorrespondence: Khalid A Kheirallah, Jordan University of Science and Technology, P. O.Box 3030, Irbid, 22110, Jordan, Email kkheiral@gmail.comPurpose: Young women are at risk of acute coronary syndrome (ACS). They represent a unique population exposed to traditional cardiovascular risk factors and female sex-specific, non-traditional risk factors. The current study aimed to describe traditional and non-traditional risk factors of ACS in young women from the Middle East.Patients and Methods: The present study used data from the Jordanian, nationwide, multicenter, case-control study, ANCORS-YW. Bivariate analyses and logistic regression models were used to predict independent risk factors of ACS using adjusted odds ratios (AOR) and 95% confidence intervals (CI).Results: The study included 572 young women (≤ 50-years) with a median age of 45-years, divided into an ACS group (n=154, 26.9%) and a control group with no atherosclerotic cardiovascular disease (n=418, 73.1%). The most common presentation of ACS was non-ST-elevation ACS (n=98, 64%). The ACS group, compared to control group, had higher proportions of type-2 diabetes (41.6%vs.11.7%, p< 0.001), hypertension (53.9%vs.23.4%, p< 0.001), tobacco use (37.7%vs.24.2%, p=0.001), family history of cardiovascular disease (53.2%vs.23.4%, p< 0.001), metabolic syndrome (14.3%vs.2.4%, p< 0.001), and preterm delivery (24.7%vs.16.7%, p=0.032). ACS group had nonsignificantly greater proportions of hypertensive disorders of pregnancy (29.2%vs.22.7%, p=0.109) and gestational diabetes (15.6%vs.10.3%, p=0.081). Multivariable logistic regression analyses identified five independent predictors of ACS: type-2 diabetes (AOR, 95% CI: 3.45, 1.98&boxh;5.99), family history of cardiovascular disease (3.33, 2.15&boxh;5.17), tobacco use (2.01, 1.26&boxh;3.21), hypertension (1.72, 1.07&boxh;2.78), and metabolic syndrome (4.35, 1.72&boxh;11.03).Conclusion: Modifiable risk factors play an important role in ACS risk among young women. Efforts should be made to improve primordial and primary prevention in this population.Keywords: cardiovascular, female, ischemic heart disease, prevention, myocardial infarctionhttps://www.dovepress.com/traditional-and-non-traditional-risk-factors-of-acute-coronary-syndrom-peer-reviewed-fulltext-article-IJWHcardiovascularfemaleischemic heart diseasepreventionmyocardial infarction.
spellingShingle Ibdah R
Al-Nusair M
Abuhalimeh R
Mahmoud SA
Laswi B
Rawashdeh S
Hamoudeh A
Kheirallah KA
Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study
International Journal of Women's Health
cardiovascular
female
ischemic heart disease
prevention
myocardial infarction.
title Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study
title_full Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study
title_fullStr Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study
title_full_unstemmed Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study
title_short Traditional and Non-Traditional Risk Factors of Acute Coronary Syndrome in Young Women: Evidence from the ANCORS-YW Study
title_sort traditional and non traditional risk factors of acute coronary syndrome in young women evidence from the ancors yw study
topic cardiovascular
female
ischemic heart disease
prevention
myocardial infarction.
url https://www.dovepress.com/traditional-and-non-traditional-risk-factors-of-acute-coronary-syndrom-peer-reviewed-fulltext-article-IJWH
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