Potential benefits of vitamin A and its derivatives in glaucoma
Abstract Vitamin A (VA), which plays a vital role in maintaining normal eye functions, has shown potential benefits in glaucoma based on accumulating evidence. The purpose of this review is to comprehensively summarize the possible role of VA and VA derivatives in the prevention and treatment of gla...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02780-4 |
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| author | Xinyue Zhang Honghao Yang Xiaoyu Zhou Jiahao Xu Jiawei Chen Li Liao Ping Wu Xuanchu Duan |
| author_facet | Xinyue Zhang Honghao Yang Xiaoyu Zhou Jiahao Xu Jiawei Chen Li Liao Ping Wu Xuanchu Duan |
| author_sort | Xinyue Zhang |
| collection | DOAJ |
| description | Abstract Vitamin A (VA), which plays a vital role in maintaining normal eye functions, has shown potential benefits in glaucoma based on accumulating evidence. The purpose of this review is to comprehensively summarize the possible role of VA and VA derivatives in the prevention and treatment of glaucoma, explore their mechanisms of action, suggest future research directions, and provide references for relevant researchers. Regarding the correlation between VA intake and glaucoma, researchers in different regions have conducted a series of studies, but most of them are cross-sectional studies. The results of different studies vary greatly and there are conflicting results, but the results of several systematic reviews and meta-analysis suggest that dietary VA intake can help reduce the risk of glaucoma. If increasing total dietary VA intake is successful as an effective prevention strategy, this would be a promising approach for primary prevention of glaucoma. Further, we summarized a large number of mechanism studies which have demonstrated the mechanisms of how VA might play a role in the prevention and treatment of glaucoma by inhibiting the oxidative stress process of trabecular meshwork and optic nerve tissue, reversing the effect of TGF-β2 on human trabecular meshwork cells and increasing intracranial pressure. Additionally, studies have also shown that VA and its derivatives could also play a role in preventing postoperative scarring and damage of the ocular surface due to the use of antiglaucoma drugs through a variety of mechanisms. |
| format | Article |
| id | doaj-art-a904a2025c1c49b4b77a1cab9405f84e |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-a904a2025c1c49b4b77a1cab9405f84e2025-08-20T03:03:27ZengBMCEuropean Journal of Medical Research2047-783X2025-07-013011910.1186/s40001-025-02780-4Potential benefits of vitamin A and its derivatives in glaucomaXinyue Zhang0Honghao Yang1Xiaoyu Zhou2Jiahao Xu3Jiawei Chen4Li Liao5Ping Wu6Xuanchu Duan7Aier Glaucoma Institute, Hunan Engineering Research Center for Glaucoma With Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Glaucoma Diagnosis and Treatment Technology Innovation Center, Changsha Aier Eye HospitalTibet UniversityAier Glaucoma Institute, Hunan Engineering Research Center for Glaucoma With Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Glaucoma Diagnosis and Treatment Technology Innovation Center, Changsha Aier Eye HospitalAier Glaucoma Institute, Hunan Engineering Research Center for Glaucoma With Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Glaucoma Diagnosis and Treatment Technology Innovation Center, Changsha Aier Eye HospitalAier Glaucoma Institute, Hunan Engineering Research Center for Glaucoma With Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Glaucoma Diagnosis and Treatment Technology Innovation Center, Changsha Aier Eye HospitalAier School of Ophthalmology, Central South UniversityAier School of Ophthalmology, Central South UniversityAier Glaucoma Institute, Hunan Engineering Research Center for Glaucoma With Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Glaucoma Diagnosis and Treatment Technology Innovation Center, Changsha Aier Eye HospitalAbstract Vitamin A (VA), which plays a vital role in maintaining normal eye functions, has shown potential benefits in glaucoma based on accumulating evidence. The purpose of this review is to comprehensively summarize the possible role of VA and VA derivatives in the prevention and treatment of glaucoma, explore their mechanisms of action, suggest future research directions, and provide references for relevant researchers. Regarding the correlation between VA intake and glaucoma, researchers in different regions have conducted a series of studies, but most of them are cross-sectional studies. The results of different studies vary greatly and there are conflicting results, but the results of several systematic reviews and meta-analysis suggest that dietary VA intake can help reduce the risk of glaucoma. If increasing total dietary VA intake is successful as an effective prevention strategy, this would be a promising approach for primary prevention of glaucoma. Further, we summarized a large number of mechanism studies which have demonstrated the mechanisms of how VA might play a role in the prevention and treatment of glaucoma by inhibiting the oxidative stress process of trabecular meshwork and optic nerve tissue, reversing the effect of TGF-β2 on human trabecular meshwork cells and increasing intracranial pressure. Additionally, studies have also shown that VA and its derivatives could also play a role in preventing postoperative scarring and damage of the ocular surface due to the use of antiglaucoma drugs through a variety of mechanisms.https://doi.org/10.1186/s40001-025-02780-4GlaucomaVitamin ARetinolOcular surface damage |
| spellingShingle | Xinyue Zhang Honghao Yang Xiaoyu Zhou Jiahao Xu Jiawei Chen Li Liao Ping Wu Xuanchu Duan Potential benefits of vitamin A and its derivatives in glaucoma European Journal of Medical Research Glaucoma Vitamin A Retinol Ocular surface damage |
| title | Potential benefits of vitamin A and its derivatives in glaucoma |
| title_full | Potential benefits of vitamin A and its derivatives in glaucoma |
| title_fullStr | Potential benefits of vitamin A and its derivatives in glaucoma |
| title_full_unstemmed | Potential benefits of vitamin A and its derivatives in glaucoma |
| title_short | Potential benefits of vitamin A and its derivatives in glaucoma |
| title_sort | potential benefits of vitamin a and its derivatives in glaucoma |
| topic | Glaucoma Vitamin A Retinol Ocular surface damage |
| url | https://doi.org/10.1186/s40001-025-02780-4 |
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